Physiological role of nitric oxide as an enhancer of oxygen transfer from erythrocytes to tissues

被引：52

作者：

Kosaka, H

Seiyama, A

机构：

[1] 1st Department of Physiology, Medical School, Osaka University, Suita, Osaka 565

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 218卷 / 03期

关键词：

D O I：

10.1006/bbrc.1996.0133

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study revealed the physiological role of NO as an enhancer of oxygen release from erythrocytes to peripheral tissue by breaking or stretching the heme iron-proximal histidine bond in the a subunit of hemoglobin (Hb), while maintaining oxygen binding capacity by restoring the bond in the lungs. Oxygen affinity was significantly decreased in blood containing NO-bound Hb a. The results may partly explain nitrosothiols in blood as an NO reservoir for an emergency and why cytokines induce NO synthase in the vascular system during such events as inflammation. (C) 1996 Academic Press, Inc.

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页码：749 / 752

页数：4

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