Role of biochemical markers of bone turnover as prognostic indicator of successful osteoporosis therapy

被引：66

作者：

Reginster, Jean-Yves ^{[1
]}

Collette, Julien ^{[1
]}

Neuprez, Audrey ^{[1
]}

Zegels, Brigitte ^{[1
]}

Deroisy, Rita ^{[1
]}

Bruyere, Olivier ^{[1
]}

机构：

[1] Univ Liege, CHU Sart Tilman, Dept Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium

来源：

BONE | 2008年 / 42卷 / 05期

关键词：

osteoporosis; monitoring; treatment; bone density; markers of bone turnover;

D O I：

10.1016/j.bone.2008.01.021

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Most of the currently available anti-osteoporosis medications promptly and significantly influence the rate of bone turnover. Biochemical markers of bone turnover now provide a high sensitivity to change, allowing the detection of these bone turnover changes within a couple of weeks. Since the anti-fracture efficacy of inhibitors of bone resorption or stimulators of bone formation appears to be largely independent of baseline bone turnover, biochemical markers do not appear to play a significant role in the selection of one particular drug, for an individual patient. However, there are consistent data showing that short-term changes in biochemical markers of bone turnover may be significant predictors of future changes in bone mineral density or fracture reduction, hence suggesting that bone turnover markers play a significant role in the monitoring of anti-osteoporosis therapy. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：832 / 836

页数：5

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