Differential effects of estrogen on hippocampal- and striatal-dependent learning

被引：90

作者：

Davis, DM ^{[1
]}

Jacobson, TK ^{[1
]}

Aliakbari, S ^{[1
]}

Mizumori, SJY ^{[1
]}

机构：

[1] Univ Washington, Dept Psychol, Seattle, WA 98195 USA

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2005年 / 84卷 / 02期

关键词：

estrogen; memory systems; working memory; reference memory; cognitive strategy;

D O I：

10.1016/j.nlm.2005.06.004

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Estrogen's role in learning and memory may be to predispose animals to use specific cognitive strategies (Korol & Kolo, 2002). Specifically, estrogen may facilitate hippocampal-dependent learning, while at the same time attenuate striatal-dependent learning. As a stringent test of this hypothesis, place or response learning on an eight-arm radial maze was compared between ovariectomized (OVX) female Long-Evans rats and rats with chronic estrogen replacement (OVX + E; 5 mg 17-beta estradiol 60-day release tablet). Reference and working memory errors were monitored separately for both place and response learning tasks. OVX + E rats learned the place task significantly faster than the response task, and faster than OVX rats. OVX rats required fewer days to reach criterion on the response task than OVX + E rats. Estrogen selectively enhanced reference memory performance, but only during place learning. The specific pattern of estrogen effects on learning suggests that future studies include verification of cognitive strategies used by animals. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：132 / 137

页数：6

共 32 条

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