Estrogen receptors: orchestrators of pleiotropic cellular responses

被引：178

作者：

Moggs, JG ^{[1
]}

Orphanides, G ^{[1
]}

机构：

[1] Syngenta Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England

来源：

EMBO REPORTS | 2001年 / 2卷 / 09期

关键词：

D O I：

10.1093/embo-reports/kve185

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Estrogen receptors (ERs) orchestrate both transcriptional and non-genomic functions in response to estrogens, xenoestrogens and signals emanating from growth factor signalling pathways. The pleiotropic and tissue-specific effects of estrogens are likely to be mediated by the differential expression of distinct estrogen receptor subtypes (ER alpha and ER beta) and their coregulators. The recent analysis of transcription complexes associated with estrogen-responsive promoters has revealed unexpected levels of complexity in the dynamics of ER-mediated transcription. Furthermore, a small fraction of ERs also appears to directly interact with components of the cytosolic signalling machinery. Analysis of the interrelationship between these distinct modes of ER action is likely to reveal novel aspects of estrogen signalling that will impact on nuclear receptor biology and human health.

引用

页码：775 / 781

页数：7

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