Kinetic evaluation of the effect of layer by layer deposition of polyelectrolytes on the stability of POPC liposomes

被引：13

作者：

Angelini, G. ^{[1
]}

Boncompagni, S. ^{[2
]}

De Maria, P. ^{[1
]}

Fontana, A. ^{[1
]}

Gasbarri, C. ^{[1
]}

Siani, G. ^{[1
]}

机构：

[1] Univ G dAnnunzio, Dipartimento Sci Farmaco, I-66013 Chieti, Italy

[2] Univ G dAnnunzio, Ctr Sci Invecchiamento, Lab Fisiol Cellulare, I-66013 Chieti, Italy

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2008年 / 322卷 / 1-3期

关键词：

kinetics; breakdown; coated liposomes; polyelectrolytes;

D O I：

10.1016/j.colsurfa.2008.03.015

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Layer by layer (LBL) assembly of poly(sodium 4-styrenesulfonate) (PSS) and poly(allylamine hydrochloride) (PAH) was used to coat positively as well as negatively charged liposomes. The adsorption of either polyelectrolyte onto the liposomal surface occurs by means of electrostatic and hydrophobic interactions, depending on the structure of the polymer. The stability of the surface-modified liposomes was evaluated by monitoring the rate of the breakdown induced by the addition of increasing amounts of octaethyleneglycol mono-n-dodecylether (C12E8). Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) yielded insight into the morphology of the capsules before and after the impact with the surfactant. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：234 / 238

页数：5

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