The planar cell polarity (PCP) signaling system governs many aspects of polarized cell behavior. Here, we use an in vivo model of vertebrate mucociliary epithelial development to show that Dishevelled (Dvl) is essential for the apical positioning of basal bodies. We find that Dvl and Inturned mediate the activation of the Rho GTPase specifically at basal bodies, and that these three proteins together mediate the docking of basal bodies to the apical plasma membrane. Moreover, we find that this docking involves a Dvl-dependent association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein, Sec8. Once docked, basal bodies again require Dvl and Rho for the planar polarization that underlies directional beating of cilia. These results demonstrate previously undescribed functions for PCP signaling components and suggest that a common signaling apparatus governs both apical docking and planar polarization of basal bodies.
机构:
Univ Virginia, Morphogenesis & Regenerat Med Inst, Charlottesville, VA 22903 USAUniv Virginia, Morphogenesis & Regenerat Med Inst, Charlottesville, VA 22903 USA
Adler, PN
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Zhu, CM
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机构:Univ Virginia, Morphogenesis & Regenerat Med Inst, Charlottesville, VA 22903 USA
Zhu, CM
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Stone, D
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机构:Univ Virginia, Morphogenesis & Regenerat Med Inst, Charlottesville, VA 22903 USA
机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Chen, W
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ten Berge, D
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机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
ten Berge, D
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Brown, J
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机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Brown, J
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Ahn, S
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机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Ahn, S
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Hu, LA
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机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Hu, LA
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Miller, WE
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机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Miller, WE
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Caron, MG
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机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Caron, MG
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Barak, LS
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机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Barak, LS
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Nusse, R
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机构:
Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USAStanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Nusse, R
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Lefkowitz, RJ
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机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
机构:
Univ Virginia, Morphogenesis & Regenerat Med Inst, Charlottesville, VA 22903 USAUniv Virginia, Morphogenesis & Regenerat Med Inst, Charlottesville, VA 22903 USA
Adler, PN
;
Zhu, CM
论文数: 0引用数: 0
h-index: 0
机构:Univ Virginia, Morphogenesis & Regenerat Med Inst, Charlottesville, VA 22903 USA
Zhu, CM
;
Stone, D
论文数: 0引用数: 0
h-index: 0
机构:Univ Virginia, Morphogenesis & Regenerat Med Inst, Charlottesville, VA 22903 USA
机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Chen, W
;
ten Berge, D
论文数: 0引用数: 0
h-index: 0
机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
ten Berge, D
;
Brown, J
论文数: 0引用数: 0
h-index: 0
机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Brown, J
;
Ahn, S
论文数: 0引用数: 0
h-index: 0
机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Ahn, S
;
Hu, LA
论文数: 0引用数: 0
h-index: 0
机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Hu, LA
;
Miller, WE
论文数: 0引用数: 0
h-index: 0
机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Miller, WE
;
Caron, MG
论文数: 0引用数: 0
h-index: 0
机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Caron, MG
;
Barak, LS
论文数: 0引用数: 0
h-index: 0
机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Barak, LS
;
Nusse, R
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USAStanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA
Nusse, R
;
Lefkowitz, RJ
论文数: 0引用数: 0
h-index: 0
机构:Stanford Univ, Sch Med, Beckman Ctr, Dept Dev Biol,Howard Hughes Med Inst, Stanford, CA 94305 USA