Non-nociceptive capsaicin-sensitive nerve terminal stimulation allows for an original vasodilatory reflex in the human skin

被引:84
作者
Fromy, B [1 ]
Abraham, P [1 ]
Saumet, JL [1 ]
机构
[1] CHU Angers, Lab Physiol & Explorat Vasc, F-49033 Angers 01, France
关键词
C fiber; neural control of skin blood flow; pressure strain; laser Doppler; human;
D O I
10.1016/S0006-8993(98)00973-1
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
A significant increase of cutaneous laser Doppler flowmetry was found before blood flow decreases with increasing pressure during a 5 mmHg min(-1) increase of pressure strain on the finger. Pre-treatment with a local anaesthetic or chronically applied capsaicin, resulted in the disappearance of the vasodilatory response. These results suggest an original vasodilatory axon reflex response to non-noxious pressure strain which is initiated by capsaicin-sensitive nerve terminals in the human skin. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:166 / 168
页数:3
相关论文
共 10 条
[1]
Action of cholinesters on sensory nerve endings in skin and muscle [J].
Carr, RW ;
Proske, U .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1996, 23 (05) :355-362
[2]
NOCIFENSIVE RESPONSES TO CUTANEOUS THERMAL STIMULI IN THE CAT - STIMULUS-RESPONSE PROFILES, LATENCIES, AND AFFERENT ACTIVITY [J].
CASEY, KL ;
MORROW, TJ .
JOURNAL OF NEUROPHYSIOLOGY, 1983, 50 (06) :1497-1515
[3]
A COMPARISON OF FORCE AND DEPTH OF SKIN INDENTATION UPON PSYCHOPHYSICAL FUNCTIONS OF TACTILE INTENSITY [J].
GREENSPAN, JD .
SOMATOSENSORY RESEARCH, 1984, 2 (01) :33-48
[4]
TACTILE SENSIBILITY IN THE HUMAN HAND - RELATIVE AND ABSOLUTE DENSITIES OF 4 TYPES OF MECHANORECEPTIVE UNITS IN GLABROUS SKIN [J].
JOHANSSON, RS ;
VALLBO, AB .
JOURNAL OF PHYSIOLOGY-LONDON, 1979, 286 (JAN) :283-300
[5]
PRIMATE CUTANEOUS SENSORY UNITS WITH UNMYELINATED-(C) AFFERENT-FIBERS [J].
KUMAZAWA, T ;
PERL, ER .
JOURNAL OF NEUROPHYSIOLOGY, 1977, 40 (06) :1325-1338
[6]
Heat-evoked vasodilatation in human hairy skin: Axon reflexes due to low-level activity of nociceptive afferents [J].
Magerl, W ;
Treede, RD .
JOURNAL OF PHYSIOLOGY-LONDON, 1996, 497 (03) :837-848
[7]
Mayrovitz HN, 1996, WOUNDS, V8, P200
[8]
SCHMIDT R, 1995, J NEUROSCI, V15, P333
[9]
LOCAL SKIN PRESSURE AND ITS EFFECTS ON SKIN MICROCIRCULATION AS EVALUATED BY LASER DOPPLER FLUXMETRY [J].
SCHUBERT, V ;
FAGRELL, B .
CLINICAL PHYSIOLOGY, 1989, 9 (06) :535-545
[10]
MICROSTIMULATION OF SINGLE TACTILE AFFERENTS FROM THE HUMAN HAND - SENSORY ATTRIBUTES RELATED TO UNIT TYPE AND PROPERTIES OF RECEPTIVE-FIELDS [J].
VALLBO, AB ;
OLSSON, KA ;
WESTBERG, KG ;
CLARK, FJ .
BRAIN, 1984, 107 (SEP) :727-749