Potent, non-thiol inhibitors of farnesyltransferase

被引：31

作者：

Breslin, MJ ^{[1
]}

deSolms, SJ

Giuliani, EA

Stokker, GE

Graham, SL

Pompliano, DL

Mosser, SD

Hamilton, KA

Hutchinson, JH

机构：

[1] Merck Res Labs, Dept Med Chem, W Point, PA 19486 USA

[2] Merck Res Labs, Dept Canc Res, W Point, PA 19486 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(98)00586-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure-activity relationship of a series of non-thiol CaaX analogs, which are inhibitors of farnesyltransferase, is described. These inhibitors contain a substituted phenyl group at the N terminus, which may occupy a novel binding domain on the Ras protein. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3311 / 3316

页数：6

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