Nitric oxide in autoimmune disease: cytotoxic or regulatory mediator?

被引：225

作者：

Kolb, H

Kolb-Bachofen, V

机构：

[1] Diabet Res Inst, D-40225 Dusseldorf, Germany

[2] Univ Dusseldorf, Fac Med, Ctr Biomed Res, Res Grp Immunobiol, D-40001 Dusseldorf, Germany

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 12期

关键词：

D O I：

10.1016/S0167-5699(98)01366-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nitric oxide (NO) is released locally during inflammatory autoimmune diseases and is believed to contribute to tissue destruction. However, recent studies are not fully consistent with such a simple role for NO. Here, Hubert Kolb and Victoria Kolb-Bachofen discuss data that suggest a role for NO in autoimmune diseases as an important regulator of the T helper 1 (Th1)/Th2 balance.

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页码：556 / 561

页数：6

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