Event-related functional MRI: Implications for cognitive psychology

被引:118
作者
D'Esposito, M [1 ]
Zarahn, E [1 ]
Aguirre, GK [1 ]
机构
[1] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
关键词
D O I
10.1037/0033-2909.125.1.155
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Functional magnetic resonance imaging (fMRI) has rapidly emerged as a powerful technique in cognitive neuroscience. We describe and critique a new class of imaging experimental designs called event-related fMRI that exploit the temporal resolution of fMRI by modeling fMRI signal changes associated with behavioral trials as opposed to blocks of behavioral trials. Advantages of this method over block designs include the ability to (a) randomize trial presentations, (b) test for functional correlates of behavioral measures with greater power, (c) directly examine the neural correlates of temporally dissociable components of behavioral trials (e.g., the delay period of a working memory task), and (d) test for differences in the onset time of neural activity evoked by different trial types. Consequently, event-related fMRI has the potential to address a number of cognitive psychology questions with a degree of inferential and statistical power not previously available.
引用
收藏
页码:155 / 164
页数:10
相关论文
共 52 条
  • [1] AGUIRRE G, 1997, C NEUR SCO 4 ANN M, V4, P63
  • [2] Aguirre G. K., 1998, Society for Neuroscience Abstracts, V24, P898
  • [3] The variability of human, BOLD hemodynamic responses
    Aguirre, GK
    Zarahn, E
    D'Esposito, M
    [J]. NEUROIMAGE, 1998, 8 (04) : 360 - 369
  • [4] TIME COURSE EPI OF HUMAN BRAIN-FUNCTION DURING TASK ACTIVATION
    BANDETTINI, PA
    WONG, EC
    HINKS, RS
    TIKOFSKY, RS
    HYDE, JS
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1992, 25 (02) : 390 - 397
  • [5] EFFECTS OF STIMULUS RATE ON SIGNAL RESPONSE DURING FUNCTIONAL MAGNETIC-RESONANCE-IMAGING OF AUDITORY-CORTEX
    BINDER, JR
    RAO, SM
    HAMMEKE, TA
    FROST, JA
    BANDETTINI, PA
    HYDE, JS
    [J]. COGNITIVE BRAIN RESEARCH, 1994, 2 (01): : 31 - 38
  • [6] Linear systems analysis of functional magnetic resonance imaging in human V1
    Boynton, GM
    Engel, SA
    Glover, GH
    Heeger, DJ
    [J]. JOURNAL OF NEUROSCIENCE, 1996, 16 (13) : 4207 - 4221
  • [7] A parametric study of prefrontal cortex involvement in human working memory
    Braver, TS
    Cohen, JD
    Nystrom, LE
    Jonides, J
    Smith, EE
    Noll, DC
    [J]. NEUROIMAGE, 1997, 5 (01) : 49 - 62
  • [8] Functional-anatomic study of episodic retrieval II. Selective averaging of event-related fMRI trials to test the retrieval success hypothesis
    Buckner, RL
    Koutstaal, W
    Schacter, DL
    Dale, AM
    Rotte, M
    Rosen, BR
    [J]. NEUROIMAGE, 1998, 7 (03) : 163 - 175
  • [9] Functional-anatomic study of episodic retrieval using fMRI I. Retrieval effort versus retrieval success
    Buckner, RL
    Koutstaal, W
    Schacter, DL
    Wagner, AD
    Rosen, BR
    [J]. NEUROIMAGE, 1998, 7 (03) : 151 - 162
  • [10] Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging
    Buckner, RL
    Bandettini, PA
    OCraven, KM
    Savoy, RL
    Petersen, SE
    Raichle, ME
    Rosen, BR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) : 14878 - 14883