Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects

被引：61

作者：

Goyama, Susumu ^{[1
]}

Mulloy, James C. ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH 45221 USA

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2011年 / 94卷 / 02期

关键词：

Core binding factor; AML1-ETO; CBF beta-MYH11; RUNX1; Acute myeloid leukemia; ACUTE MYELOID-LEUKEMIA; CBF-BETA-SMMHC; ACUTE MYELOGENOUS LEUKEMIA; T(8/21) FUSION PROTEIN; HUMAN CD34(+) CELLS; TUMOR-SUPPRESSOR; SELF-RENEWAL; C-KIT; TRANSCRIPTIONAL REPRESSION; EMBRYONIC LETHALITY;

D O I：

10.1007/s12185-011-0858-z

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Core binding factor (CBF) acute myeloid leukemia (AML) is the most common cytogenetic subtype of AML, defined by the presence of t(8;21) or inv(16)/t(16;16). The chromosomal aberrations create AML1-ETO and CBF beta-MYH11 fusion genes that disrupt the functions of CBF, an essential transcription factor in hematopoiesis. Despite the relatively good outcome of patients with CBF-AML, only approximately half of the patients are cured with current therapy, indicating the need for improved therapeutic strategies. In this review, we summarize current knowledge regarding altered transcriptional regulation, aberrant signaling pathways, and cooperating genetic events in CBF leukemia, and discuss challenges ahead for translating these findings into the clinic.

引用

页码：126 / 133

页数：8

共 83 条

[1]

Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair [J].

Alcalay, M ;

Meani, N ;

Gelmetti, V ;

Fantozzi, A ;

Fagioli, M ;

Orleth, A ;

Riganelli, D ;

Sebastiani, C ;

Cappelli, E ;

Casciari, C ;

Sciurpi, MT ;

Mariano, AR ;

Minardi, SP ;

Luzi, L ;

Muller, H ;

Di Fiore, PP ;

Frosina, G ;

Pelicci, PG .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (11) :1751-1761

[2]

DNA Methylation Profiles and Their Relationship with Cytogenetic Status in Adult Acute Myeloid Leukemia [J].

Alvarez, Sara ;

Suela, Javier ;

Valencia, Ana ;

Fernandez, Agustin ;

Wunderlich, Mark ;

Agirre, Xabier ;

Prosper, Felipe ;

Ignacio Martin-Subero, Jose ;

Maiques, Alba ;

Acquadro, Francesco ;

Rodriguez Perales, Sandra ;

Jose Calasanz, Maria ;

Roman-Gomez, Jose ;

Siebert, Reiner ;

Mulloy, James C. ;

Cervera, Jose ;

Angel Sanz, Miguel ;

Esteller, Manel ;

Cigudosa, Juan C. .

PLOS ONE, 2010, 5 (08)

[3]

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain [J].

Amann, JM ;

Nip, J ;

Strom, DK ;

Lutterbach, B ;

Harada, H ;

Lenny, N ;

Downing, JR ;

Meyers, S ;

Hiebert, SW .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (19) :6470-6483

[4]

Implications of NRAS mutations in AML:: a study of 2502 patients [J].

Bacher, Ulrike ;

Haferlach, Torsten ;

Schoch, Claudia ;

Kern, Wolfgang ;

Schnittger, Susanne .

BLOOD, 2006, 107 (10) :3847-3853

[5]

Banker DE, 1998, CLIN CANCER RES, V4, P3051

[6]

Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO [J].

Berg, Tobias ;

Fliegauf, Manfred ;

Burger, Jan ;

Staege, Martin S. ;

Liu, Shaohua ;

Martinez, Natalia ;

Heidenreich, Olaf ;

Burdach, Stefan ;

Haferlach, Torsten ;

Werner, Milton H. ;

Luebbert, Michael .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 (11) :1728-1733

[7]

Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML) [J].

Boissel, N. ;

Leroy, H. ;

Brethon, B. ;

Philippe, N. ;

de Botton, S. ;

Auvrignon, A. ;

Raffoux, E. ;

Leblanc, T. ;

Thomas, X. ;

Hermine, O. ;

Quesnel, B. ;

Baruchel, A. ;

Leverger, G. ;

Dombret, H. ;

Preudhomme, C. .

LEUKEMIA, 2006, 20 (06) :965-970

[8]

MN1 overexpression is an important step in the development of inv(16) AML [J].

Carella, C. ;

Bonten, J. ;

Sirma, S. ;

Kranenburg, T. A. ;

Terranova, S. ;

Klein-Geltink, R. ;

Shurtleff, S. ;

Downing, J. R. ;

Zwarthoff, E. C. ;

Liu, P. P. ;

Grosveld, G. C. .

LEUKEMIA, 2007, 21 (08) :1679-1690

[9]

Kit ligand and c-Kit are expressed during early human ovarian follicular development and their interaction is required for the survival of follicles in long-term culture [J].

Carlsson, IB ;

Laitinen, MPE ;

Scott, JE ;

Louhio, H ;

Velentzis, L ;

Tuuri, T ;

Aaltonen, J ;

Ritvos, O ;

Winston, RML ;

Hovatta, O .

REPRODUCTION, 2006, 131 (04) :641-649

[10]

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia [J].

Castilla, LH ;

Garrett, L ;

Adya, N ;

Orlic, D ;

Dutra, A ;

Anderson, S ;

Owens, J ;

Eckhaus, M ;

Bodine, D ;

Liu, PP .

NATURE GENETICS, 1999, 23 (02) :144-146

← 1 2 3 4 5 6 7 8 9 →