Glutamic acid decarboxylase Gene to antigen to disease

被引：78

作者：

Lernmark, A

机构：

[1] R. H. Williams Laboratory, Department of Medicine, University of Washington, Seattle, WA

[2] R. H. Williams Laboratory, Department of Medicine, University of Washington, Seattle

来源：

JOURNAL OF INTERNAL MEDICINE | 1996年 / 240卷 / 05期

关键词：

GABA; glutamic acid decarboxylase (GAD);

D O I：

10.1046/j.1365-2796.1996.27859000.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glutamic acid decarboxylase (GAD) enzymes catalyse the formation of gamma-aminobuturic acid (GABA), which is a major transmitter in the central nervous system but also exerts functions in peripheral organs, Recent molecular analyses have revealed surprising new roles for the GAD isoforms in human diseases of autoimmune character including neurological disorders and insulin-dependent diabetes. In the 1995 Frontiers in Medicine Symposium, the coauthors of this review discussed the genetics, cell biology, molecular immunology and the role of GAD as autoantigens in human autoimmunity. Studies on disease diagnosis, prediction, and prognosis have revealed unique patterns of reactivities in both cellular and humoral immune responses, Further work will be needed to establish whether the GAD molecules can be used to treat autoimmune diseases.

引用

收藏

页码：259 / 277

页数：19

相关论文

共 85 条

[1] NONTOLERANCE AND AUTOANTIBODIES TO A TRANSGENIC SELF ANTIGEN EXPRESSED IN PANCREATIC BETA-CELLS [J].

ADAMS, TE ;

ALPERT, S ;

HANAHAN, D .

NATURE, 1987, 325 (6101) :223-228

[2] CELLULAR-IMMUNITY TO A DETERMINANT COMMON TO GLUTAMATE-DECARBOXYLASE AND COXSACKIE-VIRUS IN INSULIN-DEPENDENT DIABETES [J].

ATKINSON, MA ;

BOWMAN, MA ;

CAMPBELL, L ;

DARROW, BL ;

KAUFMAN, DL ;

MACLAREN, NK .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (05) :2125-2129

[3] AUTOANTIBODIES IN NEWLY DIAGNOSED DIABETIC CHILDREN IMMUNOPRECIPITATE HUMAN PANCREATIC-ISLET CELL-PROTEINS [J].

BAEKKESKOV, S ;

NIELSEN, JH ;

MARNER, B ;

BILDE, T ;

LUDVIGSSON, J ;

LERNMARK, A .

NATURE, 1982, 298 (5870) :167-169

[4] IDENTIFICATION OF THE 64K AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES AS THE GABA-SYNTHESIZING ENZYME GLUTAMIC-ACID DECARBOXYLASE [J].

BAEKKESKOV, S ;

AANSTOOT, HJ ;

CHRISTGAU, S ;

REETZ, A ;

SOLIMENA, M ;

CASCALHO, M ;

FOLLI, F ;

RICHTEROLESEN, H ;

CAMILLI, PD .

NATURE, 1990, 347 (6289) :151-156

[5] COMBINED ANALYSIS OF AUTOANTIBODIES IMPROVES PREDICTION OF IDDM IN ISLET-CELL ANTIBODY-POSITIVE RELATIVES [J].

BINGLEY, PJ ;

CHRISTIE, MR ;

BONIFACIO, E ;

BONFANTI, R ;

SHATTOCK, M ;

FONTE, MT ;

BOTTAZZO, GF ;

GALE, EAM .

DIABETES, 1994, 43 (11) :1304-1310

[6] GAD AUTOANTIBODIES IN IDDM, STIFF-MAN SYNDROME, AND AUTOIMMUNE POLYENDOCRINE SYNDROME TYPE-I RECOGNIZE DIFFERENT EPITOPES [J].

BJORK, E ;

VELLOSO, LA ;

KAMPE, O ;

KARLSSON, FA .

DIABETES, 1994, 43 (01) :161-165

[7] GLUCOSE REGULATION OF THE AUTOANTIGEN GAD65 IN HUMAN PANCREATIC-ISLETS [J].

BJORK, E ;

KAMPE, O ;

KARLSSON, FA ;

PIPELEERS, DG ;

ANDERSSON, A ;

HELLERSTROM, C ;

EIZIRIK, DL .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 75 (06) :1574-1576

[8] INSITU CHARACTERIZATION OF AUTOIMMUNE PHENOMENA AND EXPRESSION OF HLA MOLECULES IN THE PANCREAS IN DIABETIC INSULITIS [J].

BOTTAZZO, GF ;

DEAN, BM ;

MCNALLY, JM ;

MACKAY, EH ;

SWIFT, PGF ;

GAMBLE, DR .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (06) :353-360

[9] THE EXON-INTRON ORGANIZATION OF THE GENES (GAD1 AND GAD2) ENCODING 2 HUMAN GLUTAMATE DECARBOXYLASES (GAD(67) AND GAD(65)) SUGGESTS THAT THEY DERIVE FROM A COMMON ANCESTRAL GAD [J].

BU, DF ;

TOBIN, AJ .

GENOMICS, 1994, 21 (01) :222-228

[10] 2 HUMAN GLUTAMATE DECARBOXYLASES, 65-KDA GAD AND 67-KDA GAD, ARE EACH ENCODED BY A SINGLE GENE [J].

BU, DF ;

ERLANDER, MG ;

HITZ, BC ;

TILLAKARATNE, NJK ;

KAUFMAN, DL ;

WAGNERMCPHERSON, CB ;

EVANS, GA ;

TOBIN, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) :2115-2119

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