mRNA localization and the cytoskeleton

被引：91

作者：

de Heredia, ML

Jansen, RP

机构：

[1] Univ Munich, Gene Ctr, D-81377 Munich, Germany

[2] Univ Munich, Inst Biochem, D-81377 Munich, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 01期

关键词：

D O I：

10.1016/j.ceb.2003.11.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

mRNA localization is a widespread post-transcriptional mechanism for targeting protein synthesis to specific cellular sites. It is involved in the generation of cell polarity, asymmetric segregation of cell fate determinants and germ cell specification. Actin and microtubule filaments have key functions during RNA localization, especially during transport of mRNAs and anchoring at target sites. Recent advances in understanding the role of motors and filament systems have mainly resulted from the contribution of live imaging of mRNA movement and from the purification of putative localization ribonucleoproteins. There have also been new findings on the role of centrosomes in RNA localization.

引用

页码：80 / 85

页数：6

共 40 条

[1] Alarcón VB, 2001, J CELL SCI, V114, P1731
[2] Recognition of a bicoid mRNA localization signal by a protein complex containing swallow, Nod, and RNA binding proteins
Arn, EA
Cha, BJ
Theurkauf, WE
Macdonald, PM
[J]. DEVELOPMENTAL CELL, 2003, 4 (01) : 41 - 51
[3] A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein
Brendza, RP
Serbus, LR
Duffy, JB
Saxton, WM
[J]. SCIENCE, 2000, 289 (5487) : 2120 - 2122
[4] The Drosophila hairy RNA localization signal modulates the kinetics of cytoplasmic mRNA transport
Bullock, SL
Zicha, D
Ish-Horowicz, D
[J]. EMBO JOURNAL, 2003, 22 (10) : 2484 - 2494
[5] RNA trafficking in myelinating cells
Carson, JH
Kwon, SJ
Barbarese, E
[J]. CURRENT OPINION IN NEUROBIOLOGY, 1998, 8 (05) : 607 - 612
[6] Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior
Cha, BJ
Serbus, LR
Koppetsch, BS
Theurkauf, WE
[J]. NATURE CELL BIOLOGY, 2002, 4 (08) : 592 - 598
[7] RNP localization and transport in yeast
Chartrand, P
Singer, RH
Long, RM
[J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2001, 17 : 297 - 310
[8] The cytoplasmic dynein and kinesin motors have interdependent roles in patterning the Drosophila oocyte
Duncan, JE
Warrior, R
[J]. CURRENT BIOLOGY, 2002, 12 (23) : 1982 - 1991
[9] REQUIREMENT FOR DROSOPHILA CYTOPLASMIC TROPOMYOSIN IN OSKAR MESSENGER-RNA LOCALIZATION
ERDELYI, M
MICHON, AM
GUICHET, A
GLOTZER, JB
EPHRUSSI, A
[J]. NATURE, 1995, 377 (6549) : 524 - 527
[10] The nuclear connection in RNA transport and localization
Farina, KL
Singer, RH
[J]. TRENDS IN CELL BIOLOGY, 2002, 12 (10) : 466 - 472

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