Histaminergic regulation of NK-cells: Protection against monocyte-induced apoptosis

被引：23

作者：

Hansson, M ^{[1
]}

Asea, A ^{[1
]}

Hermodsson, S ^{[1
]}

Hellstrand, K ^{[1
]}

机构：

[1] GOTHENBURG UNIV,DEPT VIROL,S-41346 GOTHENBURG,SWEDEN

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1996年 / 44卷 / 02期

关键词：

D O I：

10.1046/j.1365-3083.1996.d01-291.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human natural killer (NK) cells with CD3(-)/56(+) phenotype) acquired features characteristic of apoptosis after incubation with autologous monocytes, as revealed by apoptotic nuclear morphology and degradation of DNA into oligonucleosomal fragments. The monocyte-induced apoptosis in NK-cells was prevented by the biogenic amine histamine at concentrations exceeding 0.1 mu M. The protective effect of histamine was blocked by the H-2-receptor (H(2)R) antagonist ranitidine but not by AH202399 A, a chemical control to ranitidine devoid of H(2)R affinity. It is concluded that histaminergic mechanisms may serve to protect NK cells from damage inflicted by products of the oxidative metabolism of monocytes.

引用

页码：193 / 196

页数：4

共 14 条

[1] Histaminergic regulation of natural killer cell-mediated clearance of tumour cells in mice [J].