The MutS C terminus is essential for mismatch repair activity in vivo

被引：24

作者：

Calmann, MA ^{[1
]}

Nowosielska, A ^{[1
]}

Marinus, MG ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01605 USA

来源：

JOURNAL OF BACTERIOLOGY | 2005年 / 187卷 / 18期

关键词：

D O I：

10.1128/JB.187.18.6577-6579.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An Escherichia coli K-12 strain was constructed with a chromosomal deletion (mutS Delta 800) in the mutS gene that produced the removal of the C-terminal 53 amino acids which are not present in the MutS crystal structure. This strain has a MutS null phenotype for mutation avoidance, antirecombination, and sensitivity to cytotoxic agents in a dam mutant background.

引用

页码：6577 / 6579

页数：3

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