Topical immunomodulators for the treatment of external genital warts, cutaneous warts and molluscum contagiosum

被引：47

作者：

Hengge, UR

Cusini, M

机构：

[1] Univ Dusseldorf, Dept Dermatol & Venerol, D-40225 Dusseldorf, Germany

[2] Osped Maggiore, STD Ctr, Inst Dermatol Sci, Milan, Italy

[3] 3M Co, Pharmaceut, St Paul, MN USA

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2003年 / 149卷

关键词：

human papillomavirus; molluscum contagiosum; imiquimod; topical immunomodulators;

D O I：

10.1046/j.0366-077X.2003.05623.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Topical immunomodulators (TIMs) include both immunostimulatory and immunosuppressive agents. Newer immunostimulatory compounds such as imidazoquinolines (e.g. imiquimod) act by cytokine secretion from monocytes/macrophages (interferon-alpha, interleukin-12, tumour-necrosis factor-alpha), leading to a Th1-dominance and cell-mediated immunity. This immune milieu has been clinically used to treat viral infections such as human papillomavirus (condyloma and common warts). herpes simplex virus and mollusca in immunocompetent and immunosuppressed patients.

引用

页码：15 / 19

页数：5

共 33 条

[1] Enhancement of the innate and cellular immune response in patients with genital warts treated with topical imiquimod cream 5% [J].