Reconstruction of the block matching profiles

被引：14

作者：

Ketheesan, N

Gaudieri, S

Witt, CS

Tay, GK

Townend, DC

Christiansen, FT

Dawkins, RL

机构：

[1] Univ Western Australia, Ctr Mol Immunol & Instrumentat, Nedlands, WA 6907, Australia

[2] Royal Perth Hosp, Dept Clin Immunol, Perth, WA 6001, Australia

[3] Univ Western Australia, Dept Pathol, Nedlands, WA 6907, Australia

来源：

HUMAN IMMUNOLOGY | 1999年 / 60卷 / 02期

基金：

英国医学研究理事会;

关键词：

histocompatibility matching techniques; tissue typing; HLA matching; bone marrow transplantation;

D O I：

10.1016/S0198-8859(98)00103-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Block matching is a valuable tool for selecting donors for bone marrow transplantation. Identical, electrophoretic profiles of unrelated bone marrow donor-recipient pairs have been shown to be associated with long-term survival and a reduction of graft versus host disease (GVHD). This study was undertaken to determine the sequences of the PCR products which are generated. PCR products obtained with beta-block primers following the amplification of DNA extracted from cell lines homozygous for 7.1 and 8.1 ancestral haplotypes were cloned and sequenced. The PCR products were characterised and the beta block profiles reconstructed. The data indicate that the profiles consist of homoduplexes and heteroduplexes which are formed by the products of probably ? different sequence locations. Human Immunology GO, 171-176 (1999). (C) American Society for Histocompatibility and Immunogenetics, 1999. Published by Elsevier Science Inc.

引用

页码：171 / 176

页数：6

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