Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19

被引：1340

作者：

Vaduganathan, Muthiah ^{[1
,2
]}

Vardeny, Orly ^{[3
,4
]}

Michel, Thomas ^{[1
,2
]}

McMurray, John J., V ^{[5
]}

Pfeffer, Marc A. ^{[1
,2
]}

Solomon, Scott D. ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Cardiovasc Div, 75 Francis St, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Minneapolis VA Hlth Care Syst, Ctr Care Delivery & Outcomes Res, Minneapolis, MN USA

[4] Univ Minnesota, Minneapolis, MN USA

[5] Univ Glasgow, Cardiovasc Res Ctr, British Heart Fdn, Glasgow, Lanark, Scotland

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2020年 / 382卷 / 17期

关键词：

CONVERTING ENZYME 2; EXPERIMENTAL AUTOIMMUNE MYOCARDITIS; SARS-CORONAVIRUS; HEART-FAILURE; HYPERTENSIVE PATIENTS; FUNCTIONAL RECEPTOR; ACE2; EXPRESSION; DOWN-REGULATION; MODULATION; OLMESARTAN;

D O I：

10.1056/NEJMsr2005760

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of renin-angiotensin-aldosterone system blockers on angiotensin-converting enzyme 2 levels and activity in humans are uncertain. The authors hypothesize that ACE2 may be beneficial rather than harmful during lung injury and suggest that RAAS-inhibitor withdrawal may be harmful in some high-risk patients with known or suspected Covid-19.

引用

收藏

页码：1653 / 1659

页数：7

相关论文

共 68 条

[1] Characteristics and outcome of viral pneumonia caused by influenza and Middle East respiratory syndrome-coronavirus infections: A 4-year experience from a tertiary care center [J].

Al-Baadani, Abeer M. ;

Elzein, Fatehi E. ;

Alhemyadi, Salwa A. ;

Khan, Osama A. ;

Albenmousa, Ali H. ;

Idrees, Majdy M. .

ANNALS OF THORACIC MEDICINE, 2019, 14 (03) :179-185

[2]

[Anonymous], EUR RESPIR J

[3]

[Anonymous], INT J COLORECTA 0224

[4]

[Anonymous], DRUG DEV RES

[5] Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State [J].

Arentz, Matt ;

Yim, Eric ;

Klaff, Lindy ;

Lokhandwala, Sharukh ;

Riedo, Francis X. ;

Chong, Maria ;

Lee, Melissa .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (16) :1612-1614

[6] Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure [J].

Basu, Ratnadeep ;

Poglitsch, Marko ;

Yogasundaram, Haran ;

Thomas, Jissy ;

Rowe, Brian H. ;

Oudit, Gavin Y. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 69 (07) :805-819

[7] Combination renin-angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions [J].

Burchill, Luke J. ;

Velkoska, Elena ;

Dean, Rachael G. ;

Griggs, Karen ;

Patel, Sheila K. ;

Burrell, Louise M. .

CLINICAL SCIENCE, 2012, 123 (11-12) :649-658

[8] Myocardial infarction increases ACE2 expression in rat and humans [J].

Burrell, LM ;

Risvanis, J ;

Kubota, E ;

Dean, RG ;

MacDonald, PS ;

Lu, S ;

Tikellis, C ;

Grant, SL ;

Lew, RA ;

Smith, AI ;

Cooper, ME ;

Johnston, CI .

EUROPEAN HEART JOURNAL, 2005, 26 (04) :369-375

[9] Evidence against a major role for angiotensin converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation [J].

Campbell, DJ ;

Zeitz, CJ ;

Esler, MD ;

Horowitz, JD .

JOURNAL OF HYPERTENSION, 2004, 22 (10) :1971-1976

[10] Importance of Rapid and Effective Reduction of Blood Pressure in Treating Hypertension for the Prevention of Cardiovascular DiseasesA Lesson from the VALUE Study [J].

Salvatore Di Somma .

High Blood Pressure & Cardiovascular Prevention, 2005, 12 (3) :135-140

← 1 2 3 4 5 6 7 →