Which treatment for nonalcoholic fatty liver disease?

被引：9

作者：

Moscatiello, S.

Marzocchi, R.

Villanova, N.

Bugianesi, E.

Marchesini, G. ^{[1
]}

机构：

[1] Alma Mater Studiorum Univ Bologna, Policlin S Orsola, Unit Clin Dietet, I-40138 Bologna, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 08期

关键词：

D O I：

10.2174/138955708784912193

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Subjects with nonalcoholic fatty liver disease are at risk of progressive liver failure. Lifestyle changes including weight-loss strategies and increased physical activity remain the first-line approach, but a few pharmacological treatments have also been successfully tested. Several drugs improve biochemistry, only a few improve histology; in all cases, the results were not sustained after treatment stop. Pharmacological treatment is not so far indicated outside controlled clinical trials with histological outcomes.

引用

页码：767 / 775

页数：9

共 100 条

[1]

Abdelmalek MF, 2001, AM J GASTROENTEROL, V96, P2711

[2] A pilot trial of pentoxifylline in nonalcoholic steatohepatitis [J].

Adams, LA ;

Zein, CO ;

Angulo, P ;

Lindor, KD .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2004, 99 (12) :2365-2368

[3] HEPATIC-EFFECTS OF DIETARY WEIGHT-LOSS IN MORBIDLY OBESE SUBJECTS [J].

ANDERSEN, T ;

GLUUD, C ;

FRANZMANN, MB ;

CHRISTOFFERSEN, P .

JOURNAL OF HEPATOLOGY, 1991, 12 (02) :224-229

[4] Nonalcoholic fatty liver disease [J].

Brunt, Elizabeth M. ;

Wong, Vincent W. -S. ;

Nobili, Valerio ;

Day, Christopher P. ;

Sookoian, Silvia ;

Maher, Jacquelyn J. ;

Bugianesi, Elisabetta ;

Sirlin, Claude B. ;

Neuschwander-Tetri, BrentA. ;

Rinella, Mary E. .

NATURE REVIEWS DISEASE PRIMERS, 2015, 1

[5] Variations in body composition and plasma lipids in response to a high-carbohydrate diet [J].

Archer, WR ;

Lamarche, B ;

Dériaz, O ;

Landry, N ;

Corneau, L ;

Després, JP ;

Bergeron, J ;

Couture, P ;

Bergeron, N .

OBESITY RESEARCH, 2003, 11 (08) :978-986

[6]

Avenell A, 2004, HEALTH TECHNOL ASSES, V8, P1

[7] A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis [J].

Basaranoglu, M ;

Acbay, O ;

Sonsuz, A .

JOURNAL OF HEPATOLOGY, 1999, 31 (02) :384-384

[8] A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis [J].

Belfort, Renata ;

Harrison, Stephen A. ;

Brown, Kenneth ;

Darland, Celia ;

Finch, Joan ;

Hardies, Jean ;

Balas, Bogdan ;

Gastaldelli, Amalia ;

Tio, Fermin ;

Pulcini, Joseph ;

Berria, Rachele ;

Ma, Jennie Z. ;

Dwivedi, Sunil ;

Havranek, Russell ;

Fincke, Chris ;

DeFronzo, Ralph ;

Bannayan, George A. ;

Schenker, Steven ;

Cusi, Kenneth .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (22) :2297-2307

[9] Behavior therapy for nonalcoholic fatty liver disease: The need for a multidisciplinary approach [J].

Bellentani, Stefano ;

Dalle Grave, Riccardo ;

Suppini, Alessandro ;

Marchesini, Giuho .

HEPATOLOGY, 2008, 47 (02) :746-754

[10] Medical consequences of obesity [J].

Bray, GA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) :2583-2589

← 1 2 3 4 5 6 7 8 9 10 →