Antibodies to oxidized LDL/β2-glycoprotein I in antiphospholipid syndrome patients with venous and arterial thromboembolism

被引：20

作者：

Pengo, V. ^{[1
]}

Bison, E. ^{[1
]}

Ruffatti, A. ^{[1
]}

Iliceto, S. ^{[1
]}

机构：

[1] Univ Padua, Div Rheumatol, Dept Clin & Expt Med, I-35100 Padua, Italy

来源：

THROMBOSIS RESEARCH | 2008年 / 122卷 / 04期

关键词：

D O I：

10.1016/j.thromres.2007.12.028

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It has been reported that IgG to oxidized LDL/beta 2-glycoprotein I (oxLDL/beta 2GPI) complexes are associated with arterial thromboembolism (TE) in patients with anti phospholipid syndrome (APS). How these antibodies behave in arterial as compared to venous TE in APS is unknown. The aim of the present study was to evaluate the association of IgG anti-oxLDL/beta 2GPI with clinical manifestations in category I APS patients. Fifty-seven APS patients with triple positivity (Lupus Anticoagulant (LAC), anti cardiolipin (aCL) and anti-beta 2-glycoprotein I (a beta 2GPI) antibodies), 28 with arterial and 29 with venous thromboembolism, were included in the study. There were no differences in the dRVVT ratio, IgG/IgM aCL and IgG/IgM a beta 2GPI titers in the two patient groups. There were no differences in the IgG (78.5 U +/- 59.8 vs. 112.2 U +/- 92.3) and IgM (16.3 U +/- 15.9 vs. 21.1 U +/- 14.3) anti-oxLDL/beta 2GPI mean values. A significant correlation was found between IgG anti-oxLDL/beta 2GPI and IgG anti-beta 2GPI titers in the whole group of APS patients. Patients in the arterial group were older and had more risk factors for atherosclerosis. Data from this study do not support the hypothesis that IgG anti-oxLDL/beta 2GPI are specifically associated to arterial TE in Category I APS patients. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：556 / 559

页数：4

共 20 条

[1] Antibodies against β2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome [J].

Ames, P. R. J. ;

Alves, J. Delgado ;

Lopez, L. R. ;

Gentile, F. ;

Margarita, A. ;

Pizzella, L. ;

Batuca, J. ;

Scenna, G. ;

Brancaccio, V. ;

Matsuura, E. .

CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2006, 13 (01) :1-9

[2]

Becarevic M, 2007, CLIN EXP RHEUMATOL, V25, P361

[3] ANTIPHOSPHOLIPID ANTIBODIES ARE NOT PRESENT IN THE MEMBRANE OF GEL-FILTERED PLATELETS OF PATIENTS WITH IGG ANTICARDIOLIPIN ANTIBODIES, LUPUS ANTICOAGULANT AND THROMBOSIS [J].

BIASIOLO, A ;

PENGO, V .

BLOOD COAGULATION & FIBRINOLYSIS, 1993, 4 (03) :425-428

[4]

BRANDT JT, 1995, THROMB HAEMOSTASIS, V74, P1185

[5] IgG antibodies that recognize epitope Gly40-Arg43 in domain I of β2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis [J].

de Laat, B ;

Derksen, RHWM ;

Urbanus, RT ;

de Groot, PG .

BLOOD, 2005, 105 (04) :1540-1545

[6] Involvement of beta(2)-glycoprotein I and anticardiolipin antibodies in oxidatively modified low-density lipoprotein uptake by macrophages [J].

Hasunuma, Y ;

Matsuura, E ;

Makita, Z ;

Katahira, T ;

Nishi, S ;

Koike, T .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1997, 107 (03) :569-573

[7] Oxidized low-density lipoprotein β2-glycoprotein I complexes and autoantibodies to oxLig-1 β2-glycoprotein I in patients with systemic lupus erythematosus and antiphospholipid syndrome [J].

Lopez, D ;

Garcia-Valladares, I ;

Palafox-Sanchez, CA ;

De La Torre, IG ;

Kobayashi, K ;

Matsuura, E ;

Lopez, LR .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2004, 121 (03) :426-436

[8] Oxidized low-density lipoprotein and β2-glycoprotein I in patients with systemic lupus erythematosus and increased carotid intima-media thickness:: implications in autoimmune-mediated atherosclerosis [J].

Lopez, LR ;

Salazar-Paramo, M ;

Palafox-Sanchez, C ;

Hurley, BL ;

Matsuura, E ;

Garcia-De La Torre, I .

LUPUS, 2006, 15 (02) :80-86

[9] OxLDL/β2GPI complexes and autoantibodies in patients with systemic lupus erythematosus, systemic sclerosis, and antiphospholipid syndrome -: Pathogenic implications for vascular involvement [J].

Lopez, LR ;

Simpson, DF ;

Hurley, BL ;

Matsuura, E .

AUTOIMMUNE DISEASES AND TREATMENT: ORGAN-SPECIFIC AND SYSTEMIC DISORDERS, 2005, 1051 :313-322

[10] Atherogenic oxidized low-density lipoprotein/β2-glycoprotein I (oxLDL/β2GPI) complexes in patients with systemic lupus erythematosus and antiphospholipid syndrome [J].

Matsuura, E. ;

Kobayashi, K. ;

Hurley, B. L. ;

Lopez, L. R. .

LUPUS, 2006, 15 (07) :478-483

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