The Effects of Ageing on Proliferation Potential, Differentiation Potential and Cell Surface Characterisation of Human Mesenchymal Stem Cells

被引：25

作者：

Fossett, Emma ^{[2
]}

Khan, Wasim S. ^{[2
]}

Pastides, Philip ^{[2
]}

Adesida, Adetola B. ^{[1
]}

机构：

[1] Univ Alberta, Dept Surg, Edmonton, AB T6G 2R3, Canada

[2] Univ Coll London, Inst Orthopaed & Musculoskeletal Sci, Royal Natl Orthopaed Hosp, Stanmore HA7 4LP, Middx, England

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2012年 / 7卷 / 04期

关键词：

Ageing; characterisation; differentiation; mesenchymal stem cells; proliferation; HUMAN BONE-MARROW; STROMAL CELLS; IN-VITRO; AGE; TRANSPLANTS; POPULATIONS; EXPRESSION; EXPANSION; GENDER;

D O I：

10.2174/157488812800793027

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stem cells (MSCs) have a great capacity for use in regenerative medicine and other clinical applications. However, one question creating curiosity of their use, is how they are affected by ageing. As we now live within an ageing population, the prevalence of age related disorders is increasing, so it is important to investigate how effectively MSCs from older patients can be expanded and differentiated in vitro before their use in autologous cell transplantation. This paper will look at how ageing effects proliferation potential, differentiation potential and cell surface characterisation of human mesenchymal stem cells.

引用

页码：282 / 286

页数：5

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