The role of tissue factor in colorectal cancer

被引：46

作者：

Lykke, J ^{[1
]}

Nielsen, HJ ^{[1
]}

机构：

[1] Hvidovre Univ Hosp, Dept Surg Gastroenterol 435, Surg Immunol Lab, Copenhagen, Denmark

来源：

EUROPEAN JOURNAL OF SURGICAL ONCOLOGY | 2003年 / 29卷 / 05期

关键词：

colorectal cancer; tissue factor; angiogenesis; surgery; infectious complications;

D O I：

10.1016/S0748-7983(03)00053-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The possible role of tissue factor (TF) in colorectal cancer (CRC) is reviewed. A correlation between TF expression and advanced stages of malignancy, and a correlation between TF expression and overall survival have been suggested in CRC. This is supported by experimental studies indicating that TF plays a key role in growth, invasion and dissemination of tumour cells, and in tumour related angiogenesis as well. In addition, the activation of TF in CRC patients in relation to the surgical trauma, perioperative blood transfusion and development of postoperative bacterial infectious complications are discussed. Finally, future directions for the development of anticancer modalities directed against regulation of TF are considered. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：417 / 422

页数：6

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