Discovery of the first series of inhibitors of human papillomavirus type 11:: Inhibition of the assembly of the E1-E2-origin DNA complex

被引：55

作者：

Yoakim, C

Ogilvie, WW

Goudreau, N

Naud, J

Haché, B

O'Meara, JA

Cordingley, MG

Archambault, J

White, PW

机构：

[1] Boehringer Ingelheim Ltd Canada, Dept Chem, Laval, PQ H7S 2G5, Canada

[2] Boehringer Ingelheim Ltd Canada, Dept Sci Biol, Laval, PQ H7S 2G5, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(03)00510-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have discovered a series of inhibitors of the assembly of the HPV11 E1-E2-origin DNA complex, which incorporate an indandione fused to a substituted tetrahydrofuran. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：2539 / 2541

页数：3

共 13 条

[1]

Beutner Karl R., 1997, American Journal of Medicine, V102, P28

[2] Imiquimod, a patient-applied immune-response modifier for treatment of external genital warts [J].

Beutner, KR ;

Tyring, SK ;

Trofatter, KF ;

Douglas, JM ;

Spruance, S ;

Owens, ML ;

Fox, TL ;

Hougham, AJ ;

Schmitt, KA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (04) :789-794

[3] PAPILLOMAVIRUS DNA-REPLICATION [J].

CHOW, LT ;

BROKER, TR .

INTERVIROLOGY, 1994, 37 (3-4) :150-158

[4]

HOWLEY PM, 1996, FIELDS VIROLOGY, P2045

[5]

KRYSIN MY, 1987, KHIM GETEROTSIKL+, P1463

[6]

MCBRIDE A, 1997, THEORETICAL BIOL BIO, P54

[7] Molecular targets for human papillomaviruses: prospects for antiviral therapy [J].

Phelps, WC ;

Barnes, JA ;

Lobe, DC .

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1998, 9 (05) :359-377

[8]

Shah KV., 1996, Virology, V3, P2077

[9]

SVERDRUP F, 1997, THEORETICAL BIOL BIO, P37

[10] FLUOROMETRIC REAGENTS FOR PRIMARY AMINES - SYNTHESES OF 2-ALKOXY-FURANONES AND 2-ACYLOXY-3(2H)-FURANONES [J].

WEIGELE, M ;

TENGI, JP ;

DEBERNARDO, S ;

CZAJKOWSKI, R ;

LEIMGRUBER, W .

JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (02) :388-389

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