Inhibition by tranilast of vascular endothelial growth factor (VEGF) vascular permeability factor (VPF)-induced increase in vascular permeability in rats

被引：16

作者：

Isaji, M

Miyata, H

Ajisawa, Y

Yoshimura, N

机构：

[1] Kissei Pharmaceut Co Ltd, Discovery Res Labs, Minamiazumi, Nagano 39983, Japan

[2] Shinshu Univ, Sch Med, Dept Ophthalmol, Matsumoto, Nagano 390, Japan

来源：

LIFE SCIENCES | 1998年 / 63卷 / 04期

关键词：

tranilast; VEGF/VPF; vascular permeability; edema; air pouch;

D O I：

10.1016/S0024-3205(98)00277-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effects of tranilast, an anti-allergic and anti-proliferative drug in clinical use, on VEGF/VPF-induced vascular permeability in a rat air pouch model. A large increase in vascular permeability was induced by injection of 4 ml of a 100 ng/ml VEGF/VPF solution into the preformed air pouch. Over a 15-min period, tranilast inhibited the VEGF/VPF-induced vascular permeability in a dose-dependent manner. This result suggests that tranilast, which we recently found to inhibit VEGF/VPF-induced angiogenesis, could also improve VEGF/VPF-dependent increases in vascular permeability. (C) 1998 Elsevier Science Inc.

引用

页码：PL71 / PL74

页数：4

共 19 条

[1] Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor [J].