Olfactory Deficits and Amyloid-β Burden in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Aging: A PiB PET Study

被引：73

作者：

Bahar-Fuchs, Alex ^{[1
,2
,3
]}

Chetelat, Gael ^{[1
,2
]}

Villemagne, Victor L. ^{[1
,2
,4
]}

Moss, Simon ^{[3
]}

Pike, Kerryn ^{[1
,2
,3
,5
]}

Masters, Colin L. ^{[4
]}

Rowe, Christopher ^{[1
,2
]}

Savage, Greg ^{[3
,6
]}

机构：

[1] Austin Hlth, Dept Nucl Med, Heidelberg, Vic, Australia

[2] Austin Hlth, Ctr PET, Heidelberg, Vic, Australia

[3] Monash Univ, Sch Psychol & Psychiat, Clayton, Vic 3800, Australia

[4] Univ Melbourne, Mental Hlth Res Inst, Parkville, Vic 3052, Australia

[5] La Trobe Univ, Sch Psychol Sci, Bundoora, Vic 3086, Australia

[6] Macquarie Univ, Macquarie Ctr Cognit Sci, N Ryde, NSW 2109, Australia

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 22卷 / 04期

关键词：

Alzheimer's disease; amyloid-beta; diagnosis; mild cognitive impairment; olfaction; PET imaging; Pittsburgh Compound B; ODOR IDENTIFICATION; DYSFUNCTION; ATROPHY;

D O I：

10.3233/JAD-2010-100696

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Olfactory deficits and increased amyloid-beta (A beta) burden are observed in people with amnestic mild cognitive impairment (aMCI); both factors may be predictive of Alzheimer's disease (AD). We explored whether olfactory identification is related to in vivo measures of A beta burden using Pittsburgh Compound B (PiB) PET. Nineteen control, 24 aMCI, and 20 AD participants completed an olfactory identification task and underwent PiB PET scanning. Control participants performed better on olfactory identification and showed lower PiB binding than aMCI patients. There was a significant correlation between both factors when pooling all groups together but not when considering each group separately. In addition, the olfactory identification score did not differ between aMCI participants who were PiB-positive and those who were PiB-negative. We conclude that AD-related olfactory identification deficits are not directly related to A beta burden.

引用

页码：1081 / 1087

页数：7

共 34 条

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