Optimized synthesis of aminooxy-peptides as glycoprobe precursors for surface-based sugar-protein interaction studies

被引：24

作者：

Jimenez-Castells, Carmen

de la Torre, Beatriz G.

Gallego, Ricardo Gutierrez

Andreu, David

机构：

[1] Pompeu Fabra Univ, Dept Expt & Hlth Sci, Barcelona 08003, Spain

[2] Municipal Inst Med Res, Pharmacol Res Unit, Barcelona 08003, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 18期

关键词：

glycoprobes; surface-based interaction studies; aminooxypeptide; coupling reagent;

D O I：

10.1016/j.bmcl.2007.06.090

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An improved procedure for solid phase coupling of Boc-arninooxyacetic acid to peptides is described. By avoiding base-containing activation mixtures which cause over-acylation, it practically suppresses this unwanted side reaction and leads to near quantitative yields of Aoa-peptides, useful as glycoprobe precursors in glycomic studies. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：5155 / 5158

页数：4

共 27 条

[1] Inhibition of HIV entry by carbohydrate-binding proteins [J].