Induction of a hexagonal phase in phospholipid-surfactant bilayers

被引:12
作者
Funari, SS [1 ]
机构
[1] Leiden Univ, Dept Phys, D-04103 Leipzig, Germany
来源
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | 1998年 / 27卷 / 06期
关键词
gel phase; micelles; aggregation number; X-ray; hydration; geometrical parameters;
D O I
10.1007/s002490050170
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
The possibility of modifying the curvature of lipid bilayers by mixing them with additives is demonstrated and the evolution of geometrical parameters with composition is discussed. X-ray diffraction patterns of the POPC/C12EO2/(H2O)-H-2 system were observed as a function of the relative humidity. The formation of an unexpected hexagonal phase indicates peculiar behaviour in these mixtures. The cylinder radius of this phase is considerably smaller than previously observed in cubic phases. A discussion of the head group interactions is presented. We have also been able to show that the uptake of water by the L-beta gel phase is higher as a single phase than in the L-beta+H-II two phase region. The water content is important for the stabilization of H-II phase and determination of its characteristic dimensions. However, it is argued that the interaction between the surfactant and the lipid is the key factor for its formation and that the EO2 head groups displace water from the inner parts of the polar region of the mesogenic units.
引用
收藏
页码:590 / 594
页数:5
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