Partial protective effect of inactivated Japanese encephalitis vaccine on lethal West Nile virus infection in mice

被引：46

作者：

Takasaki, T ^{[1
]}

Yabe, S ^{[1
]}

Nerome, R ^{[1
]}

Ito, M ^{[1
]}

Yamada, KI ^{[1
]}

Kurane, I ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Shinjuku Ku, Dept Virol 1, Tokyo 1628640, Japan

来源：

VACCINE | 2003年 / 21卷 / 31期

关键词：

West Nile virus; Japanese encephalitis virus; flaviviridae; vaccine;

D O I：

10.1016/S0264-410X(03)00507-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of mouse brain-derived, inactivated Japanese encephalitis (JE) vaccine on West Nile virus (WNV) infection was examined using a murine model. Mice were immunized with JE vaccine twice and challenged with lethal doses of WNV. When mice were intracranially challenged with WNV, none of the immunized mice were protected. When mice were intraperitoneally challenged, the immunized mice were protected at higher immunization levels. Cross-reactive neutralizing antibodies to WNV were induced by immunization with JE vaccine; however, the levels were much lower than those to JEV. These results indicate that the currently available mouse brain-derived inactivated JE vaccine can induce partial protective immunity to WNV in mice. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：4514 / 4518

页数：5

共 10 条

[1] ANTIGENIC RELATIONSHIP OF WEST NILE STRAINS BY TITER RATIOS CALCULATED FROM CROSS-NEUTRALIZATION TEST-RESULTS [J].

BLACKBURN, NK ;

THOMPSON, DL ;

JUPP, PG .

EPIDEMIOLOGY AND INFECTION, 1987, 99 (02) :551-557

[2]

*CDC, MMWR, V251, P1129

[3]

*CDCP, 2001, MMWR-MORBID MORTAL W, V50, P1061

[4]

GOVERDHAN MK, 1992, ACTA VIROL

[5] Short report: Absence of protective neutralizng antibodies to West Nile virus in subjects following vaccination with Japanese encephalitis or dengue vaccines [J].

Kanesa-Thasan, N ;

Putnak, JR ;

Mangiafico, JA ;

Saluzzo, JF ;

Ludwig, GV .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2002, 66 (02) :115-116

[6] Immunogenicity and protective efficacy of the current inactivated Japanese encephalitis vaccine against different Japanese encephalitis virus strains [J].

Kurane, I ;

Takasaki, T .

VACCINE, 2000, 18 :33-35

[7] Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States [J].

Lanciotti, RS ;

Roehrig, JT ;

Deubel, V ;

Smith, J ;

Parker, M ;

Steele, K ;

Crise, B ;

Volpe, KE ;

Crabtree, MB ;

Scherret, JH ;

Hall, RA ;

MacKenzie, JS ;

Cropp, CB ;

Panigrahy, B ;

Ostlund, E ;

Schmitt, B ;

Malkinson, M ;

Banet, C ;

Weissman, J ;

Komar, N ;

Savage, HM ;

Stone, W ;

McNamara, T ;

Gubler, DJ .

SCIENCE, 1999, 286 (5448) :2333-2337

[8]

Monath TP, 2001, ANN NY ACAD SCI, V951, P1

[9]

OYA A, 1988, Acta Paediatrica Japonica, V30, P175

[10] Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis [J].

Tesh, RB ;

da Rosa, APAT ;

Guzman, H ;

Araujo, TP ;

Xiao, SY .

EMERGING INFECTIOUS DISEASES, 2002, 8 (03) :245-251

← 1 →