Is there really a relationship between the plasma concentration of the active metabolite of clopidogrel and the results of platelet function tests?

被引:12
作者
Delavenne, X. [1 ,2 ,3 ]
Mallouk, N. [2 ,3 ]
Piot, M. [2 ,3 ]
Mismetti, P. [2 ,3 ,4 ]
Laporte, S. [2 ,3 ,4 ]
机构
[1] CHU St Etienne, Lab Pharmacol Toxicol, St Etienne, France
[2] Univ Lyon, St Etienne, France
[3] Univ St Etienne, Grp Rech Thrombose, St Etienne, France
[4] CHU St Etienne, Unite Rech Clin Innovat & Pharmacol, St Etienne, France
关键词
PERCUTANEOUS CORONARY INTERVENTION; LC-MS/MS; RESPONSIVENESS; METAANALYSIS; ASSOCIATION; INHIBITION; ASPIRIN;
D O I
10.1111/j.1538-7836.2010.04004.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:2334 / 2338
页数:5
相关论文
共 26 条
[1]   CYP2C19*2 polymorphism is not the sole determinant of the response to clopidogrel: implications for its monitoring [J].
Aleil, B. ;
Leon, C. ;
Cazenave, J. -P. ;
Gachet, C. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 (10) :1747-1749
[2]   Clopidogrel 150 mg/day to Overcome Low Responsiveness in Patients Undergoing Elective Percutaneous Coronary Intervention Results From the VASP-02 (Vasodilator-Stimulated Phosphoprotein-02) Randomized Study [J].
Aleil, Boris ;
Jacquemin, Laurent ;
De Poli, Fabien ;
Zaehringer, Michel ;
Collet, Jean-Philippe ;
Montalescot, Gilles ;
Cazenave, Jean-Pierre ;
Dickele, Marie-Claude ;
Monassier, Jean-Pierre ;
Gachet, Christian .
JACC-CARDIOVASCULAR INTERVENTIONS, 2008, 1 (06) :631-638
[3]   ACC/AHA 2007 guide lines for the management of patients with unstable Angina/Non-ST-Elevation myocardial infraction - Executive summary [J].
Anderson, Jeffrey L. ;
Adams, Cynthia D. ;
Antman, Elliott M. ;
Bridges, Charles R. ;
Califf, Robert M. ;
Casey, Donald E., Jr. ;
Chavey, William E., II ;
Fesmire, Francis M. ;
Hochman, Judith S. ;
Levin, Thomas N. ;
Lincoff, A. Michael ;
Peterson, Eric D. ;
Theroux, Pierre ;
Wenger, Nanette Kass ;
Wright, R. Scott ;
Smith, Sidney C., Jr. ;
Jacobs, Alice K. ;
Adams, Cynthia D. ;
Riegel, Barbara .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (07) :652-726
[4]   Assessment, Mechanisms, and Clinical Implication of Variability in Platelet Response to Aspirin and Clopidogrel Therapy [J].
Ben-Dor, Itsik ;
Kleiman, Neal S. ;
Lev, Eli .
AMERICAN JOURNAL OF CARDIOLOGY, 2009, 104 (02) :227-233
[5]   Relation of Body Mass Index to High On-Treatment Platelet Reactivity and of Failed Clopidogrel Dose Adjustment According to Platelet Reactivity Monitoring in Patients Undergoing Percutaneous Coronary Intervention [J].
Bonello-Palot, Nathalie ;
Armero, Sebastien ;
Paganelli, Franck ;
Mancini, Julien ;
De labriolle, Axel ;
Bonello, Caroline ;
Levy, Nicolas ;
Maillard, Luc ;
Barragan, Paul ;
Dignat-George, Francoise ;
Camoin-Jau, Laurence ;
Bonello, Laurent .
AMERICAN JOURNAL OF CARDIOLOGY, 2009, 104 (11) :1511-1515
[6]   Which platelet function test is suitable to monitor clopidogrel responsiveness? A pharmacokinetic analysis on the active metabolite of clopidogrel [J].
Bouman, H. J. ;
Parlak, E. ;
van Werkum, J. W. ;
Breet, N. J. ;
ten Cate, H. ;
Hackeng, C. M. ;
ten Berg, J. M. ;
Taubert, D. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2010, 8 (03) :482-488
[7]   A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation [J].
Brandt, John T. ;
Payne, Christopher D. ;
Wiviott, Stephen D. ;
Weerakkody, Govinda ;
Farid, Nagy A. ;
Small, David S. ;
Jaknbowski, Joseph A. ;
Naganuma, Hideo ;
Winters, Kenneth J. .
AMERICAN HEART JOURNAL, 2007, 153 (01) :66.e9-66.e16
[8]   Clinical implications of clopidogrel non-response in cardiovascular patients: a systematic review and meta-analysis [J].
Combescure, C. ;
Fontana, P. ;
Mallouk, N. ;
Berdague, P. ;
Labruyere, C. ;
Barazer, I. ;
Gris, J. C. ;
Laporte, S. ;
Fabbro-Peray, P. ;
Reny, J. L. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2010, 8 (05) :923-933
[9]   Ultra-performance LC MS/MS method for quantification of clopidogrel active metabolite [J].
Delavenne, Xavier ;
Basset, Thierry ;
Zufferey, Paul ;
Malouk, Nora ;
Laporte, Silvy ;
Mismetti, Patrick .
JOURNAL OF SEPARATION SCIENCE, 2010, 33 (13) :1968-1972
[10]  
Ellis KJ, 2009, PHARMACOGENOMICS, V10, P1799, DOI [10.2217/pgs.09.143, 10.2217/PGS.09.143]