NO-releasing NSAIDs are caspase inhibitors

被引：48

作者：

Fiorucci, S ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Clin Med & Sperimentale, Clin Gastroenterol & Endoscopia Digest, I-06100 Perugia, Italy

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 05期

关键词：

D O I：

10.1016/S1471-4906(01)01904-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nitrosation of thiol-containing proteins is a mechanism for cell regulation. Nitric-oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs) are chemical entities obtained by adding a nitroxybutyl moiety to a conventional NSAID. NO-NSAIDs inhibit inflammation via cyclo-oxygenase (COX)dependent and-independent effects. Similarly to endogenous NO, NO-NSAIDs are potent inhibitors of T helper1 (Th1) type cytokines. This effect is largely owing to post-translational nitrosation and therefore inactivation of cysteine proteases, such as the interleukin (IL)-1 beta converting enzyme (ICE/caspase-1) involved in pro-cytokine processing.

引用

页码：232 / 235

页数：4

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