Impact of smoking on lung cancer treatment effectiveness: a review

被引：63

作者：

Condoluci, Adalgisa ^{[1
]}

Mazzara, Calogero ^{[2
]}

Zoccoli, Alice ^{[2
]}

Pezzuto, Aldo ^{[3
]}

Tonini, Giuseppe ^{[2
]}

机构：

[1] San Giovanni Hosp, Thorac Surg Unit, Bellinzona, Switzerland

[2] Univ Campus Biomed Rome, Dept Oncol, Rome, Italy

[3] Sapienza Univ, St Andrea Hosp, Cardiovasc & Pulm Dept, Rome, Italy

来源：

FUTURE ONCOLOGY | 2016年 / 12卷 / 18期

关键词：

cigarette smoke compounds; lung cancer pathways; nicotine metabolism; RECEPTOR-MEDIATED ACTIVATION; QUALITY-OF-LIFE; CIGARETTE-SMOKING; CYTOCHROME-P450; 2A6; CELL-PROLIFERATION; NICOTINE; RESISTANCE; GENE; GROWTH; POLYMORPHISMS;

D O I：

10.2217/fon-2015-0055

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Tobacco smoke contains more than 4000 detectable substances, such as polycyclic aromatic hydrocarbons, nicotine, carbon monoxide and heavy metals, which are considered powerful enzymatic inducers that have notable influence on the efficacy and tolerability of many medications through complex pharmacokinetic and pharmacodynamic interactions. As a result, adjustments of drug dosages are required in smokers, both if they continue to smoke or if they quit after smoking cessation treatment. The purpose of this review is to examine the main drug interactions with tobacco smoke clinically relevant, with a closer look on patients developing oncologic diseases.

引用

页码：2149 / 2161

页数：13

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