A convenient rhodium-catalyzed intermolecular hydroamination procedure for terminal alkynes

被引：125

作者：

Hartung, CG

Tillack, A

Trauthwein, H

Beller, M

机构：

[1] Univ Rostock eV, Inst Organ Katalyseforsch, D-18055 Rostock, Germany

[2] Aventis R&T, Ind Pk Hochst, D-65926 Frankfurt, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 19期

关键词：

D O I：

10.1021/jo010444t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first rhodium-catalyzed intermolecular hydroamination of alkynes is presented. Terminal alkynes react efficiently with anilines in the presence of cationic rhodium(I) catalysts under very mild reaction conditions (e.g., base and acid free at room temperature) to yield up to 99% of the corresponding imines. An easy one-pot protocol for the synthesis of secondary amines was developed by combining this alkyne amination reaction with in situ addition of organolithium reagents.

引用

页码：6339 / 6343

页数：5

共 51 条

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