Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP:: tipping the scales of cancer

被引：775

作者：

Frescas, David ^{[1
]}

Pagano, Michele ^{[1
]}

机构：

[1] NYU, Sch Med, NYU Canc Ctr, New York, NY 10016 USA

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 06期

关键词：

D O I：

10.1038/nrc2396

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The maintenance and preservation of distinct phases during the cell cycle is a highly complex and coordinated process. It is regulated by phosphorylation - through the activity of cyclin-dependent kinases (CDKs) - and protein degradation, which occurs through ubiquitin ligases such as SCF (SKP1 - CUL1 - F-box protein) complexes and APC/C (anaphase-promoting complex/cyclosome). Here, we explore the functionality and biology of the F-box proteins, SKP2 (S-phase kinase-associated protein 2) and beta-TrCP (beta-transducin repeat-containing protein), which are emerging as important players in cancer biogenesis owing to the deregulated proteolysis of their substrates.

引用

收藏

页码：438 / 449

页数：12

相关论文

共 192 条

[1] Development of the proteasome inhihitor Veleade™ (Bortezomib) [J].

Adams, J ;

Kauffman, M .

CANCER INVESTIGATION, 2004, 22 (02) :304-311

[2] Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis [J].

Afonja, O ;

Juste, D ;

Das, S ;

Matsuhashi, S ;

Samuels, HH .

ONCOGENE, 2004, 23 (49) :8135-8145

[3] APC/CCdc20 controls the ubiquitin-mediated degradation of p21 in prometaphase [J].

Amador, Virginia ;

Ge, Sheng ;

Santamaria, Patricia G. ;

Guardavaccaro, Daniele ;

Pagano, Michele .

MOLECULAR CELL, 2007, 27 (03) :462-473

[4] Mechanism of processing of the NF-κB2 p100 precursor:: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCFβ-TrCP ubiquitin ligase [J].

Amir, RE ;

Haecker, H ;

Karin, M ;

Ciechanover, A .

ONCOGENE, 2004, 23 (14) :2540-2547

[5] Nuclear factor-κB and liver carcinogenesis [J].

Arsura, M ;

Cavin, LG .

CANCER LETTERS, 2005, 229 (02) :157-169

[6] NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry [J].

Bassermann, F ;

von Klitzing, C ;

Münch, S ;

Bai, RY ;

Kawaguchi, H ;

Morris, SW ;

Peschel, C ;

Duyster, J .

CELL, 2005, 122 (01) :45-57

[7]

Bellan C, 2002, INVEST OPHTH VIS SCI, V43, P3602

[8] HIV-1 Vpu sequesters β-transducin repeat-containing protein (βTrCP) in the cytoplasm and provokes the accumulation of β-catenin and other SCFβTrCP substrates [J].

Besnard-Guerin, C ;

Belaïdouni, N ;

Lassot, I ;

Segeral, E ;

Jobart, A ;

Marchal, C ;

Benarous, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (01) :788-795

[9] Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells [J].

Bhatt, K. V. ;

Hu, R. ;

Spofford, L. S. ;

Aplin, A. E. .

ONCOGENE, 2007, 26 (07) :1056-1066

[10] Deregulated degradation of the cdk inhibitor p27 and malignant transformation [J].

Bloom, J ;

Pagano, M .

SEMINARS IN CANCER BIOLOGY, 2003, 13 (01) :41-47

← 1 2 3 4 5 6 7 8 9 10 →