The Impact of the Gut Microbiota on Human Health: An Integrative View

被引：2716

作者：

Clemente, Jose C. ^{[1
]}

Ursell, Luke K. ^{[1
]}

Parfrey, Laura Wegener ^{[1
]}

Knight, Rob ^{[1
,2
]}

机构：

[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

[2] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA

来源：

CELL | 2012年 / 148卷 / 06期

关键词：

HELICOBACTER-PYLORI INFECTION; INFLAMMATORY-BOWEL-DISEASE; GENOME-WIDE ASSOCIATION; INTESTINAL MICROBIOTA; BACTERIAL COMMUNITY; CROHNS-DISEASE; ULCERATIVE-COLITIS; IMMUNE-RESPONSES; IDENTICAL-TWINS; GIARDIA-LAMBLIA;

D O I：

10.1016/j.cell.2012.01.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human gut harbors diverse microbes that play a fundamental role in the well-being of their host. The constituents of the microbiota-bacteria, viruses, and eukaryotes-have been shown to interact with one another and with the host immune system in ways that influence the development of disease. We review these interactions and suggest that a holistic approach to studying the microbiota that goes beyond characterization of community composition and encompasses dynamic interactions between all components of the microbiota and host tissue over time will be crucial for building predictive models for diagnosis and treatment of diseases linked to imbalances in our microbiota.

引用

页码：1258 / 1270

页数：13

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