Bats Worldwide Carry Hepatitis E Virus-Related Viruses That Form a Putative Novel Genus within the Family Hepeviridae

被引：215

作者：

Drexler, Jan Felix ^{[1
]}

Seelen, Annika ^{[1
]}

Corman, Victor Max ^{[1
]}

Tateno, Adriana Fumie ^{[1
]}

Cottontail, Veronika ^{[2
]}

Zerbinati, Rodrigo Melim ^{[1
]}

Gloza-Rausch, Florian ^{[1
,3
]}

Klose, Stefan M. ^{[1
,2
]}

Adu-Sarkodie, Yaw ^{[5
]}

Oppong, Samuel K. ^{[5
]}

Kalko, Elisabeth K. V. ^{[2
,4
]}

Osterman, Andreas ^{[6
]}

Rasche, Andrea ^{[7
]}

Adam, Alexander ^{[8
]}

Mueller, Marcel A. ^{[1
]}

Ulrich, Rainer G. ^{[9
]}

Leroy, Eric M. ^{[10
]}

Lukashev, Alexander N. ^{[11
]}

Drosten, Christian ^{[1
]}

机构：

[1] Univ Bonn, Inst Virol, Med Ctr, Bonn, Germany

[2] Univ Ulm, Inst Expt Ecol, Ulm, Germany

[3] Noctalis, Ctr Bat Protect & Informat, Bad Segeberg, Germany

[4] Smithsonian Trop Res Inst, Balboa, Panama

[5] Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana

[6] Max von Pettenkofer Inst, Dept Virol, Munich, Germany

[7] Univ Vet Med Hannover, Hannover, Germany

[8] Univ Cologne, Inst Pathol, Med Ctr, Cologne, Germany

[9] Inst Novel & Emerging Infect Dis, Friedrich Loeffler Inst, Greifswald, Germany

[10] Ctr Int Rech Med Franceville, Unite Malad Virales Emergentes, Franceville, Gabon

[11] Chumakov Inst Poliomyelitis & Viral Encephalitide, Moscow, Russia

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 17期

关键词：

HIGHLY PREVALENT; PREGNANT-WOMEN; ORF3; PROTEIN; C VIRUS; INFECTION; RNA; TRANSMISSION; ANTIBODIES; SWINE; HEV;

D O I：

10.1128/JVI.00800-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis E virus (HEV) is one of the most common causes of acute hepatitis in tropical and temperate climates. Tropical genotypes 1 and 2 are associated with food-borne and waterborne transmission. Zoonotic reservoirs (mainly pigs, wild boar, and deer) are considered for genotypes 3 and 4, which exist in temperate climates. In view of the association of several zoonotic viruses with bats, we analyzed 3,869 bat specimens from 85 different species and from five continents for hepevirus RNA. HEVs were detected in African, Central American, and European bats, forming a novel phylogenetic clade in the family Hepeviridae. Bat hepeviruses were highly diversified and comparable to human HEY in sequence variation. No evidence for the transmission of bat hepeviruses to humans was found in over 90,000 human blood donations and individual patient sera. Full-genome analysis of one representative virus confirmed formal classification within the family Hepeviridae. Sequence- and distance-based taxonomic evaluations suggested that bat hepeviruses constitute a distinct genus within the family Hepeviridae and that at least three other genera comprising human, rodent, and avian hepeviruses can be designated. This may imply that hepeviruses invaded mammalian hosts nonrecently and underwent speciation according to their host restrictions. Human HEY-related viruses in farmed and peridomestic animals might represent secondary acquisitions of human viruses, rather than animal precursors causally involved in the evolution of human HEV.

引用

页码：9134 / 9147

页数：14

共 75 条

[1] Hepatitis E virus infection is highly prevalent among pregnant women in Accra, Ghana [J].