Coexistence of two distinct secretion mutations (P5T and I97L) in hepatitis B virus core produces a wild-type pattern of secretion

被引：16

作者：

Chua, PK

Wen, YM

Shih, CH ^{[1
]}

机构：

[1] Univ Texas, Med Branch, Dept Pathol, Ctr Trop Dis, Galveston, TX 77555 USA

[2] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[3] Fudan Univ, Med Ctr, Dept Mol Virol, Shanghai 200032, Peoples R China

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 13期

关键词：

D O I：

10.1128/JVI.77.13.7673-7676.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Unlike a Tokyo isolate of hepatitis B virus variants, we found a Shanghai isolate that secretes few virions with an immature genome despite its core I97L mutation. Core mutations P5T and I97L were found to be mutually compensatory in offsetting their respective distinct effects on virion secretion.

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页码：7673 / 7676

页数：4

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