Detection of DNA hybridization by gold nanoparticle enhanced transmission surface plasmon resonance spectroscopy

被引：103

作者：

Hutter, E ^{[1
]}

Pileni, MP ^{[1
]}

机构：

[1] Univ Paris 06, Lab Mat Mesoscop & Nanometr, LM2N, CNRS UMR 7070, F-75005 Paris, France

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2003年 / 107卷 / 27期

关键词：

D O I：

10.1021/jp0342834

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Self-assembly of a submonolayer of thiolated DNA and mercaptohexanol spacer, as well as the DNA hybridization, could be readily sensed by gold nanoislands deposited on a glass slide by transmission surface plasmon resonance (T-SPR) spectroscopy. The sensitivity of T-SPR dramatically increased by the functionalization of the complementary DNA by 11.7 ± 1.9 nm gold nanoparticles. This enhanced sensitivity is rationalized by the constructive interactions of the gold nanoisland and gold nanoparticle surface plasmon resonances.

引用

页码：6497 / 6499

页数：3

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