Role of cGMP signals in tetramethylpyrazine induced relaxation of the isolated rat aortic strip

被引：9

作者：

Tsai, CC ^{[1
]}

Lai, TY

Huang, WC

Liu, IM

Liou, SS

机构：

[1] China Med Univ, Sch Postbaccalaureate Chinese Med, Taichung 40402, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 70101, Taiwan

[3] Tajen Inst Technol, Dept Pharm, Ping Tung Shien 90701, Taiwan

来源：

LIFE SCIENCES | 2005年 / 77卷 / 13期

关键词：

aortic rings; cGMP; guanylyl cyclase; phosphodiestrase; PKG; TMP;

D O I：

10.1016/j.lfs.2004.12.045

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

In the present study, role of guanosine-3',5'-cyclic monophosphate (cGMP) in the vasodilatation of tetramethylpyrazine (TMP), one of the active ingredients of the Chinese herb Chuang-xion, was investigated. We found that the TMP could decrease the vascular tone of isolated rat aorta precontracted with phenylephrine (10(-8) M) in a concentration-dependent manner from 10(-5) M to 10(-3) M. Also, the TMP-induced relaxation was reduced by 1H-(1,2,4)-oxadiazol-(4,3-a)-quinoxalin-1-one (ODQ) or methylene blue, the inhibitor of soluble guanylyl cyclase. Moreover, the vasodilative response to TMP was enhanced significantly in the presence of sildenafil, a well-known inhibitor of phosphodiestrase type 5 that is sensitive to cGMP. In addition, TMP could increase the cGMP level in the isolated aortic rings and TMP-induced vasodilatation was deleted by cGMP-dependent protein kinases (PKG) blockade. These results suggest that relaxation of rat aortic strip by TMP is induced in the cGMP-dependent manner. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1416 / 1424

页数：9

共 30 条

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