Anti-hepatotoxic activity of cichotyboside, a sesquiterpene glycoside from the seeds of Cichorium intybus

被引：40

作者：

Ahmed, Bahar ^{[1
]}

Khan, Shamshir ^{[1
]}

Masood, Mubashir H. ^{[1
]}

Siddique, Anwarul H. ^{[1
]}

机构：

[1] Hamdard Univ, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2008年 / 10卷 / 03期

关键词：

anti-hepatotoxic activity; carbon tetrachloride; Cichorium intybus; silymarin;

D O I：

10.1080/10286020701590764

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The seeds of Cichorium intybus L. (Asteraceae) afforded a new guaianolide sesquiterpene glycoside, cichotyboside, which was characterized as 2, 6, 7, 15-tetrahydroxy-1 (10), 4 (5)-diene-guaian-9, 12-olide-7-O--caffoyl-15-O--D-glucoside (1) by means of spectral methods. Cichotyboside (1) exhibited a significant anti-hepatotoxic activity against CCl4 induced toxicity in Wistar rats, wherein it reduced the elevated levels of liver enzymes such as serum glutamate oxaloacetate transaminase (SGOT) by 52 units/ml; SGPT 38 units/ml; ALKP 24.97 units/ml and 7.54g/dl, 5.48g/dl increase in total protein and albumin, respectively. It was observed that cichotyboside (1) decreased the level of ALKP comparable with that of standard drug silymarin, exhibiting an 88% decrease in comparison to silymarin (92%) and increased the level of total albumin 85% in comparison to silymarin (89%) against intoxicated control. Whereas, the levels of SGOT and SGPT were also decreased considerably in comparison to standard and intoxicated control.

引用

页码：218 / 223

页数：6

共 14 条

[1]

Antihepatotoxic activity of seeds of Cichorium intybus [J].