Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila

被引：248

作者：

LaFever, L ^{[1
]}

Drummond-Barbosa, D ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Cell & Dev Biol, Nashville, TN 37232 USA

来源：

SCIENCE | 2005年 / 309卷 / 5737期

关键词：

D O I：

10.1126/science.1111410

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stem cells reside in specialized niches that provide signals required for their maintenance and division. Tissue-extrinsic signals can also modify stem cell activity, although this is poorly understood. Here, we report that neural-derived Drosophila insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating the ovarian response to nutritional input can modify stem cell activity in a niche-independent manner. We also reveal a crucial direct role of DILPs in controlling germline cyst growth and vitellogenesis.

引用

页码：1071 / 1073

页数：3

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