Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury

被引：100

作者：

Jiang, W. ^{[1
]}

Huang, Y. ^{[2
]}

Han, N. ^{[2
]}

He, F. ^{[1
]}

Li, M. ^{[1
]}

Bian, Z. ^{[1
]}

Liu, J. ^{[2
]}

Sun, T. ^{[2
]}

Zhu, L. ^{[1
]}

机构：

[1] Nanjing Med Univ, Hangzhou Hosp, Hangzhou Peoples Hosp 1, Dept Orthoped, 261 Huansha Rd, Hangzhou 310000, Zhejiang, Peoples R China

[2] Beijing Mil Command, Gen Hosp, Dept Orthoped, Beijing, Peoples R China

来源：

SPINAL CORD | 2016年 / 54卷 / 08期

关键词：

THIOREDOXIN-INTERACTING PROTEIN; TNF-ALPHA; REDUCES INFILTRATION; SIGNALING PATHWAY; ANIMAL-MODEL; INTERLEUKIN-1; APOPTOSIS; IL-1-BETA; RECOVERY; CELLS;

D O I：

10.1038/sc.2015.227

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Study design: Randomized experimental study. Objectives: To investigate the molecular mechanisms of quercetin in spinal cord injury (SCI) rats. Setting: China. Methods: One hundred female Sprague-Dawley rats were randomly assigned into four groups: sham group, SCI group, SCI+Vehicle (Veh) group, and the SCI+Quercetin (Que) group. The influences of quercetin on proinflammatory cytokine levels, histological changes and locomotion scale were estimated. Results: SCI significantly promoted nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome activation and increased proinflammatory cytokine productions in the SCI group as compared with the sham group. Quercetin administration significantly decreased reactive oxygen species production, inhibited NLRP3 inflammasome activation and reduced inflammatory cytokine levels. Moreover, quercetin administration attenuated histopathology and promoted locomotion recovery. Conclusion: Quercetin can attenuate tissue damage and improve neurological function recovery, and the mechanism may be related to the inhibition of NLRP3 inflammasome activation.

引用

页码：592 / 596

页数：5

共 39 条

[1]

Interleukin-1 receptor antagonist attenuates the severity of spinal cord ischemic injury in rabbits [J].