Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

被引：605

作者：

Galli, Stephen J. ^{[1
]}

Grimbaldeston, Michele ^{[1
,2
]}

Tsai, Mindy ^{[1
]}

机构：

[1] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA

[2] Inst Med & Vet Sci, Div Human Immunol, Hanson Inst, Adelaide, SA 5000, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 06期

关键词：

D O I：

10.1038/nri2327

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mast cells can promote inflammation and other tissue changes in IgE-associated allergic disorders, as well as in certain innate and adaptive immune responses that are thought to be independent of IgE. However, mast cells can also have anti-inflammatory and immunosuppressive functions. Here, we review the evidence that mast cells can have negative, as well as positive, immunomodulatory roles in vivo, and we propose that mast cells can both enhance and later suppress certain features of an immune response.

引用

页码：478 / U14

页数：9

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