Beneficial and preventive effect of chitin nanofibrils in a dextran sulfate sodium-induced acute ulcerative colitis model

被引：53

作者：

Azuma, Kazuo ^{[1
]}

Osaki, Tomohiro ^{[1
]}

Wakuda, Takashi ^{[1
]}

Ifuku, Shinsuke ^{[2
]}

Saimoto, Hiroyuki ^{[2
]}

Tsuka, Takeshi ^{[1
]}

Imagawa, Tomohiro ^{[1
]}

Okamoto, Yoshiharu ^{[1
]}

Minami, Saburo ^{[1
]}

机构：

[1] Tottori Univ, Dept Vet Clin Med, Tottori 6808553, Japan

[2] Tottori Univ, Dept Chem & Biotechnol, Tottori 6808550, Japan

来源：

CARBOHYDRATE POLYMERS | 2012年 / 87卷 / 02期

关键词：

Chitin nanofibrils; Inflammatory bowel disease; Dextran sulfate sodium-induced colitis; Mouse; INFLAMMATORY-BOWEL-DISEASE; ACETYL-D-GLUCOSAMINE; COMPLEMENT; NEUTROPHIL; MANAGEMENT; CHITOSAN; ALPHA; MICE;

D O I：

10.1016/j.carbpol.2011.09.036

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Chitin nanofibrils, which are prepared from dried crab shells by a grinding method, are newly developed natural materials with uniform widths of approximately 10-20 nm. The bioactivities of chitin nanofibrils have not been investigated. In this study, we examined the preventive effects of chitin nanofibrils in a mouse model of dextran sulfate sodium (DSS)-induced acute ulcerative colitis. The results indicated that chitin nanofibrils improved clinical symptoms and suppressed ulcerative colitis. Furthermore, chitin nanofibrils suppressed myeloperoxidase activation in the colon and decreased serum interleukin-6 concentrations. Conversely, chitin powder did not suppress DSS-induced acute ulcerative colitis. Our results suggested that chitin nanofibrils have potential as a functional substance for inflammatory bowel disease patients. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1399 / 1403

页数：5

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