Induction of mucosal immunity with a replication-defective adenoviral recombinant

被引：24

作者：

Xiang, ZQ ^{[1
]}

Ertl, HCJ ^{[1
]}

机构：

[1] Wistar Inst, Philadelphia, PA 19104 USA

来源：

VACCINE | 1999年 / 17卷 / 15-16期

关键词：

mucosal immunity; vaccines; recombinant vaccine;

D O I：

10.1016/S0264-410X(98)00449-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A replication-defective adenoviral recombinant expressing the rabies virus glycoprotein was tested for induction of transgene specific central and mucosal antibodies upon systemic inoculation or upon application to the mucosa of the airways, the rectum or the female genital tract. Mice developed serum and mucosal antibody titers to rabies virus upon subcutaneous or intranasal immunization with the latter route favoring induction of genital and intestinal secretion of antibodies of the IgA isotype. Immunization through the mucose of the genital tract or the rectum was inefficient. Mucosal and systemic antibody liters could be increased by intranasal priming followed by a booster immunization with the same construct. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：2003 / 2008

页数：6

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