Immunogenetics - Defence by diversity

被引：26

作者：

Hill, AVS ^{[1
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England

[2] Univ Oxford, Inst Mol Med, Oxford, England

来源：

NATURE | 1999年 / 398卷 / 6729期

关键词：

D O I：

10.1038/19431

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The variety of human leukocyte antigens (HLAs) is yet another level of variation in the immune system, and it's long been thought that HLAs may be associated with susceptibility to disease. Two large-scale studies now strengthen this view, linking HLAs with susceptibility after infection with HIV-1 and the human T-lymphotropic virus-1.

引用

页码：668 / 669

页数：2

共 14 条

[1] The nature of selection on the major histocompatibility complex
Apanius, V
Penn, D
Slev, PR
Ruff, LR
Potts, WK
[J]. CRITICAL REVIEWS IN IMMUNOLOGY, 1997, 17 (02) : 179 - 224
[2] Genetic diversity of HLA-A2: Evolutionary and functional significance
Browning, M
Krausa, P
[J]. IMMUNOLOGY TODAY, 1996, 17 (04): : 165 - 170
[3] HLA and HIV-1:: Heterozygote advantage and B*35-Cw*04 disadvantage
Carrington, M
Nelson, GW
Martin, MP
Kissner, T
Vlahov, D
Goedert, JJ
Kaslow, R
Buchbinder, S
Hoots, K
O'Brien, SJ
[J]. SCIENCE, 1999, 283 (5408) : 1748 - 1752
[4] BIOLOGICAL ROLE FOR MAJOR HISTOCOMPATIBILITY ANTIGENS
DOHERTY, PC
ZINKERNAGEL, RM
[J]. LANCET, 1975, 1 (7922) : 1406 - 1409
[5] ENHANCED IMMUNOLOGICAL SURVEILLANCE IN MICE HETEROZYGOUS AT H-2 GENE COMPLEX
DOHERTY, PC
ZINKERNAGEL, RM
[J]. NATURE, 1975, 256 (5512) : 50 - 52
[6] Association of malaria parasite population structure, HLA, and immunological antagonism
Gilbert, SC
Plebanski, M
Gupta, S
Morris, J
Cox, M
Aidoo, M
Kwiatkowski, D
Greenwood, BM
Whittle, HC
Hill, AVS
[J]. SCIENCE, 1998, 279 (5354) : 1173 - 1177
[7] The immunogenetics of human infectious diseases
Hill, AVS
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 : 593 - 617
[8] COMMON WEST AFRICAN HLA ANTIGENS ARE ASSOCIATED WITH PROTECTION FROM SEVERE MALARIA
HILL, AVS
ALLSOPP, CEM
KWIATKOWSKI, D
ANSTEY, NM
TWUMASI, P
ROWE, PA
BENNETT, S
BREWSTER, D
MCMICHAEL, AJ
GREENWOOD, BM
[J]. NATURE, 1991, 352 (6336) : 595 - 600
[9] HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy
Jeffery, KJM
Usuku, K
Hall, SE
Matsumoto, W
Taylor, GP
Procter, J
Bunce, M
Ogg, GS
Welsh, KI
Weber, JN
Lloyd, AL
Nowak, MA
Nagai, M
Kodama, D
Izumo, S
Osame, M
Bangham, CRM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) : 3848 - 3853
[10] Human leukocyte antigen matching and fetal Loss: results of a 10 year prospective study
Ober, C
Hyslop, T
Elias, S
Weitkamp, LR
Hauck, WW
[J]. HUMAN REPRODUCTION, 1998, 13 (01) : 33 - 38

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