A novel serum chitinase that is expressed in bovine liver

被引：30

作者：

Suzuki, M

Morimatsu, M

Yamashita, T

Iwanaga, T

Syuto, B

机构：

[1] Iwate Univ, Fac Agr, Dept Vet Med, Morioka, Iwate 0208550, Japan

[2] Hokkaido Univ, Grad Sch Vet Med, Kita Ku, Sapporo, Hokkaido 0600818, Japan

来源：

FEBS LETTERS | 2001年 / 506卷 / 02期

关键词：

chitin; mammalian chitinase; bovine serum; liver; innate immunity;

D O I：

10.1016/S0014-5793(01)02893-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chitinases are ubiquitous chitin-fragmenting hydrolases. They are synthesized by a vast array of organisms, including those not composed of chitin. Here, we describe a novel serum chitinase (chitin-binding protein b04, CBPb04), which is expressed in bovine liver. Although CBPb04 is secreted as an endocrine chitinase, it shows higher homology with human gastrointestinal tract exocrine chitinase (AMCase) than with macrophage endocrine chitinase (human chitotriosidase). This suggests that cows have a specific defense against chitin-containing microorganisms. CBPb04 mRNA is expressed in hepatocytes. This is the first report of a hepatogenic mammalian chitinase. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：127 / 130

页数：4

共 20 条

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Bleau G, 1999, EXS, V87, P211

[2] CLONING OF A CDNA-ENCODING CHITOTRIOSIDASE, A HUMAN CHITINASE PRODUCED BY MACROPHAGES [J].