Small peptide inhibitors of alpha(4)beta(7) mediated MAdCAM-1 adhesion to lymphocytes

被引：14

作者：

Shroff, HN ^{[1
]}

Schwender, CF ^{[1
]}

Dottavio, D ^{[1
]}

Yang, LL ^{[1
]}

Briskin, MJ ^{[1
]}

机构：

[1] LEUKOSITE INC,CAMBRIDGE,MA 02142

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 21期

关键词：

D O I：

10.1016/0960-894X(96)00469-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Specificity of leukocyte trafficking to intestinal mucosal tissues is largely mediated by MAdCAM-1/alpha(4) beta(7) interaction. A series of small peptides was prepared to establish L-D-T-S-L as a recognition motif involved in the alpha(4) beta(7) interaction. N-Terminus acylation of the L-D-T-S-L motif has led to low micromolar inhibitors of leukocyte adhesion. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2495 / 2500

页数：6

共 13 条

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