Enantioselective hydrogenation of pyrrolidine-2,3,5-triones over the Pt-cinchonidine system

被引：38

作者：

Szabo, A ^{[1
]}

Künzle, N ^{[1
]}

Mallat, T ^{[1
]}

Baiker, A ^{[1
]}

机构：

[1] ETH Zentrum, Swiss Fed Inst Technol, Tech Chem Lab, CH-8092 Zurich, Switzerland

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(98)00499-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

1- and I-Substituted pyrrolidine-2,3,5-triones 5, 6 and 9 have been synthesized and hydrogenated to 3-hydroxy derivatives 10-12 with 17-91% ee using a 5 wt% Pt/Al2O3 catalyst in the presence of small amounts of cinchonidine. The influence of substituents on the enantioselectivity is discussed. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：61 / 76

页数：16

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