Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

被引：2187

作者：

Zlokovic, Berislav V. ^{[1
,2
]}

机构：

[1] Univ So Calif, Dept Physiol & Biophys, Zilkha Neurogenet Inst, Keck Sch Med, Los Angeles, CA 90089 USA

[2] Univ So Calif, Ctr Neurodegenerat & Regenerat, Zilkha Neurogenet Inst, Keck Sch Med, Los Angeles, CA 90089 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2011年 / 12卷 / 12期

基金：

美国国家卫生研究院;

关键词：

BLOOD-BRAIN-BARRIER; AMYLOID-BETA-PEPTIDE; AMYOTROPHIC-LATERAL-SCLEROSIS; RECEPTOR-RELATED PROTEIN-1; CENTRAL-NERVOUS-SYSTEM; CEREBRAL MICROVASCULAR PATHOLOGY; MILD COGNITIVE IMPAIRMENT; MOTOR-NEURON DEGENERATION; TRANSGENIC MOUSE MODEL; GUINEA-PIG BRAIN;

D O I：

10.1038/nrn3114

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neurovascular unit (NVU) comprises brain endothelial cells, pericytes or vascular smooth muscle cells, glia and neurons. The NVU controls blood-brain barrier (BBB) permeability and cerebral blood flow, and maintains the chemical composition of the neuronal 'milieu', which is required for proper functioning of neuronal circuits. Recent evidence indicates that BBB dysfunction is associated with the accumulation of several vasculotoxic and neurotoxic molecules within brain parenchyma, a reduction in cerebral blood flow, and hypoxia. Together, these vascular-derived insults might initiate and/or contribute to neuronal degeneration. This article examines mechanisms of BBB dysfunction in neurodegenerative disorders, notably Alzheimer's disease, and highlights therapeutic opportunities relating to these neurovascular deficits.

引用

页码：723 / 738

页数：16

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