Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34

被引:38
作者
Hofmann, TG
Mincheva, A
Lichter, P
Dröge, W
Schmitz, ML
机构
[1] German Canc Res Ctr, Div Immunochem G0200, D-69120 Heidelberg, Germany
[2] German Canc Res Ctr, Div Org Complex Genomes, D-69120 Heidelberg, Germany
关键词
chromosomal localization; HIPK2; protein kinase; phosphorylation;
D O I
10.1016/S0300-9084(00)01196-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Here we identified the human serine/threonine kinase HIPK2 as a novel member of the DYRK kinase subfamily. Alignment of several DYRK family proteins including the kinases minibrain, MJAK, PKY, the Dictyostelium kinase YakA and Saccharomyces YAK1 allowed the identification of several evolutionary conserved DYRK consensus motifs within the kinase domain. A lysine residue conserved between all DYRK kinase family members was found to be essential for the kinase function of HIPK2. Human HIPK2 was mapped to chromosome 7q32-q34 and murine HIPK2 to chromosome 6B, the homologue to human chromosome 7. (C) 2000 Societe francaise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:1123 / 1127
页数:5
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